AI Article Synopsis
- Brain organoids are lab-created, 3D brain tissue made from pluripotent stem cells, allowing researchers to study brain development and diseases.
- Traditional 3D cultures have limitations, especially in replicating certain physiological conditions like signaling gradients.
- The new Brain Organoid-on-a-Chip platforms can create these gradients, resulting in more accurate models of human brain regions for detailed analysis of neurodevelopment and diseases.
Article Abstract
Brain organoids are three-dimensionally reconstructed brain tissue derived from pluripotent stem cells in vitro. 3D tissue cultures have opened new avenues for exploring development and disease modeling. However, some physiological conditions, including signaling gradients in 3D cultures, have not yet been easily achieved. Here, we introduce Brain Organoid-on-a-Chip platforms that generate signaling gradients that in turn enable the induction of topographic forebrain organoids. This creates a more continuous spectrum of brain regions and provides a more complete mimic of the human brain for evaluating neurodevelopment and disease in unprecedented detail.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541131 | PMC |
| http://dx.doi.org/10.1101/2023.09.18.558278 | DOI Listing |
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View Article and Find Full Text PDFArticle Synopsis
- Brain organoids are lab-created, 3D brain tissue made from pluripotent stem cells, allowing researchers to study brain development and diseases.
- Traditional 3D cultures have limitations, especially in replicating certain physiological conditions like signaling gradients.
- The new Brain Organoid-on-a-Chip platforms can create these gradients, resulting in more accurate models of human brain regions for detailed analysis of neurodevelopment and diseases.
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