The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539706 | PMC |
| http://dx.doi.org/10.7150/ijbs.89237 | DOI Listing |
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