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Active role of amino acid metabolism in early diagnosis and treatment of diabetic kidney disease. | LitMetric

AI Article Synopsis

  • * The development of DKD is influenced by abnormal amino acid metabolism, involving issues like oxidative stress and inflammation, and is connected to cellular processes such as autophagy and mitochondrial dysfunction.
  • * The study focuses on specific amino acids (like taurine and BCAAs), examining their effects on DKD for early diagnosis and potential treatment strategies.

Article Abstract

Diabetic Kidney Disease (DKD) is one of the significant microvascular consequences of type 2 diabetes mellitus with a complex etiology and protracted course. In the early stages of DKD, the majority of patients experience an insidious onset and few overt clinical symptoms and indicators, but they are prone to develop end-stage renal disease in the later stage, which is life-threatening. The abnormal amino acid metabolism is tightly associated with the development of DKD, which involves several pathological processes such as oxidative stress, inflammatory response, and immune response and is also closely related to autophagy, mitochondrial dysfunction, and iron death. With a focus on taurine, branched-chain amino acids (BCAAs) and glutamine, we explored the biological effects of various amino acid mechanisms linked to DKD, the impact of amino acid metabolism in the early diagnosis of DKD, and the role of amino acid metabolism in treating DKD, to offer fresh objectives and guidelines for later early detection and DKD therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539689PMC
http://dx.doi.org/10.3389/fnut.2023.1239838DOI Listing

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