AI Article Synopsis
- * Understanding how these modulators affect the microbiomes in the lungs and digestive tract is crucial for predicting disease outcomes and mechanisms.
- * This review discusses the current knowledge of CFTR modulators' effects on microbial communities and highlights the connection between lung and gut health in cystic fibrosis.
Article Abstract
The advent of CFTR modulators represents a turning point in the history of cystic fibrosis (CF) management, changing profoundly the disease's clinical course by improving mucosal hydration. Assessing changes in airway and digestive tract microbiomes is of great interest to better understand the mechanisms and to predict disease evolution. Bacterial and fungal dysbiosis have been well documented in patients with CF; yet the impact of CFTR modulators on microbial communities has only been partially deciphered to date. In this review, we aim to summarize the current state of knowledge regarding the impact of CFTR modulators on both pulmonary and digestive microbiomes. Our analysis also covers the inter-organ connections between lung and gut communities, in order to highlight the gut-lung axis involvement in CF pathophysiology and its evolution in the era of novel modulators therapies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540301 | PMC |
| http://dx.doi.org/10.3389/fcimb.2023.1271117 | DOI Listing |
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