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The early oligomers of the amyloid Aβ peptide are implicated in Alzheimer's disease, but their transient nature complicates the characterization of their structure and toxicity. Here, we investigate the stability of the minimal toxic species, i.e., β-amyloid dimers, in the presence of an oscillating electric field. We first use deep learning (AlphaFold-multimer) for generating initial models of Aβ42 dimers. The flexibility and secondary structure content of the models are then analyzed by multiple runs of molecular dynamics (MD). Structurally stable models are similar to ensemble representatives from microsecond-long MD sampling. Finally, we employ the validated model as the starting structure of MD simulations in the presence of an external oscillating electric field and observe a fast decay of β-sheet content at high field strengths. Control simulations using the helical dimer of the 42-residue leucine zipper peptide show higher structural stability than the Aβ42 dimer. The simulation results provide evidence that an external electric field (oscillating at 1 GHz) can disrupt amyloid oligomers which should be further investigated by experiments with brain organoids and eventually .
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http://dx.doi.org/10.1021/acsphyschemau.3c00021 | DOI Listing |
Talanta
March 2025
School of Materials Science and Engineering, Harbin Institute of Technology at Weihai, 2 West Wenhua Road, Weihai, 264209, China. Electronic address:
The three-dimensional (3D) semiconductor/noble metal composite substrates for surface-enhanced Raman scattering (SERS) have garnered increasing interest due to their excellent optical and chemical properties, as well as the capacity to trigger both electromagnetic mechanism (EM) and chemical mechanism (CM) simultaneously. In this work, a facile 3D urchin-like KTiO/Ag nanoparticles (Ag NPs) composite substrate is designed for multi-purpose SERS sensing. KTiO, as a dielectric medium, improves the electric field environment around Ag NPs, which is consistent with finite-different time domain (FDTD) results, and enhances the SERS performance of the KTiO/Ag composite substrate.
View Article and Find Full Text PDFEur J Cancer
March 2025
Mount Sinai Health System, New York, NY, USA. Electronic address:
Lung cancer screening implementation has led to expanded imaging of the chest in older, tobacco-exposed populations. Growing numbers of screening cases are also found to have CT-detectable emphysema or elevated levels of coronary calcium, indicating the presence of coronary artery disease. Early interventions based on these additional findings, especially with coronary calcium, are emerging and follow established protocols.
View Article and Find Full Text PDFBioelectrochemistry
March 2025
Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Poland; State Research Institute Centre for Innovative Medicine, Department of Immunology and Bioelectrochemistry, Vilnius, Lithuania.
This study explores the combination of jasplakinolide with electroporation (JSP + EP), a method enhancing targeted molecule delivery. CHO-K1 (Chinese hamster ovarian), C2C12 (mouse myoblast), and RD (rhabdomyosarcoma) cells were treated with jasplakinolide (50 nM) in HEPES buffer and exposed to electrical pulses (0.8-1.
View Article and Find Full Text PDFMed Phys
March 2025
School of Computer Science and Engineering, Central South University, Changsha, China.
Background: Quantitative susceptibility mapping (QSM) is a post-processing magnetic resonance imaging (MRI) technique that extracts the distribution of tissue susceptibilities and holds significant promise in the study of neurological diseases. However, the ill-conditioned nature of dipole inversion often results in noise and artifacts during QSM reconstruction from the tissue field. Deep learning methods have shown great potential in addressing these issues; however, most existing approaches rely on basic U-net structures, leading to limited performances and reconstruction artifacts sometimes.
View Article and Find Full Text PDFBackground: The field of sperm cryopreservation requires the search for and development of new effective cryopreservatives with low toxicity.
Objective: The purpose of this study was to evaluate the characteristics of bull spermatozoa subjected to freezing and storage at -80 degree C for 28 days in a diluent with the addition of Hericium erinaceus polysaccharides.
Materials And Methods: The sperm was frozen under the protection of a complex cryoprotectant and stored in an electric freezer at -80 degree C for 28 days.
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