AI Article Synopsis
- Bloodstream infections (BSIs) in children are a significant concern, as they can lead to high morbidity and mortality, necessitating effective and appropriate treatment to avoid worsening antibiotic resistance.
- A comprehensive five-year study analyzed 2,544 bacterial strains from 2,368 pediatric BSI patients in Beijing, focusing on the species distribution and antibiotic resistance patterns.
- Results showed that gram-positive bacteria were the primary pathogens, with coagulase-negative staphylococci (CoNS) displaying high levels of antibiotic resistance, while common gram-negative bacteria also exhibited notable resistance to crucial antibiotics.
Article Abstract
Purpose: Bloodstream infections (BSIs) was an essential cause of morbidity and mortality in children. Empiric broad-spectrum treatment of BSIs may be costly and unable to effectively eliminate the correct pathogenic microbes, resulting in downstream antimicrobial resistance. The purpose was to provide evidence for diagnosis and treatment of bloodstream infections in pediatrics, by revealing the pathogen distribution and antibiotic resistance pattern of BSIs.
Methods: In this 5-year study, a total of 2544 pathogenic bacteria stains, isolated from 2368 patients with BSI, were retrospectively analyzed, to define the species distribution and the antimicrobial resistance pattern in Beijing.
Results: The most frequently isolated pathogenic bacteria were (12.1%), (11.5%), (11.2%), and (11.2%). Hematological malignancies were the most common disease among patients with underlying conditions. Methicillin resistance was detected in 30.0% of and 81.7% of coagulase-negative (CoNS), respectively. The detection rates of carbapenem-resistant- (CRECO) and carbapenem-resistant- (CRKPN) were 10.8% and 50.8%, respectively. In terms of 122 isolates of , 5 isolates (4.1%) were penicillin-resistant (PRSP); meanwhile, 50 isolates (41.0%) were penicillin-intermediate (PISP). Among the non-fermentative gram-negative bacilli isolates, 22.8% and 26.9% of the , were resistant to imipenem and meropenem. Furthermore, the resistance rates of to imipenem and meropenem both were 54.5%.
Conclusion: In the study, we demonstrated the characteristics of bloodstream infections and antimicrobial susceptibility pattern of pediatrics in Beijing. Gram positive bacteria were the main pathogens of BSIs. CoNS strains presented even higher resistance to multiple antibiotics, including methicillin, than and represent the most common isolated gram-negative bacteria and exhibited high resistance to a variety of antimicrobial agents. Therefore, it was of critical importance to implement appropriate antimicrobial medication according to pathogen distribution and drug susceptibility test.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540788 | PMC |
| http://dx.doi.org/10.2147/IDR.S426000 | DOI Listing |
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