Morin envisions the adaptive landscape of graphic codes as an unfertile valley where writing rises as an isolated peak that humans managed to reach only on four occasions throughout all of history. By exploring the different paths to cultural convergence, we suggest an alternative landscape occupied by a mountain range of visual art systems. We conclude that graphic communication through visual art worked well enough to render writing contingent but not necessary in most cases.
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http://dx.doi.org/10.1017/S0140525X23000560 | DOI Listing |
Sci Rep
January 2025
Department of Biology, The University of Mississippi, University, MS, 38677, USA.
During development, cells of the nervous system begin as unspecified precursors and proceed along one of two developmental paths to become either neurons or glia. Work in the fruit fly Drosophila melanogaster has established the role of the transcription factor Glial cells missing (Gcm) in directing neuronal precursor cells to assume a glial cell fate. Gcm acts on many target genes, one of which is reversed polarity (repo).
View Article and Find Full Text PDFBreast Cancer Res
January 2025
Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Background: Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative breast cancer (TNBC), with lack of breastfeeding. This is more prevalent in African American women, with significantly lower rate of breastfeeding compared to Caucasian women. Prolonged breastfeeding leads to gradual involution (GI), whereas short-term or lack of breastfeeding leads to abrupt involution (AI) of the breast.
View Article and Find Full Text PDFOptical density (OD) is an important indicator of microbial density, and a commonly used variable in growth curves to express the growth of microbial culture. However, OD values show a linear relationship with bacterial concentration only at low concentrations. When the cell density is high, the relationship loses linearity, and serial dilution is needed to obtain readings of better accuracy.
View Article and Find Full Text PDFSci Transl Med
January 2025
Rady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA.
Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder, including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase signaling. encodes a key acyltransferase in PI synthesis and is mutated in an autism-related condition with neurodevelopmental delay and epilepsy. Using liquid chromatography-tandem mass spectrometry, we analyzed the PI-associated glycerolipidome in mice and humans during neurodevelopment and found dynamic regulation at times corresponding to neural apoptosis in the brains of knockout mice.
View Article and Find Full Text PDFSci Rep
December 2024
School of Business, Shanghai Dianji University, Shanghai, China.
Rural Revitalization (RR) is a key national strategy in China aimed at sustainable rural development and has gained significant attention. Given the unique characteristics of different villages, understanding differentiated paths to achieve RR is essential. This study introduces a new "5I Framework" (INDUS-INHAB-INDOC-INFRA-INCOM) to assess RR's overall development status (ODS) and differentiated paths.
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