Objectives: The objective was to examine the effect of giving Artificial Intelligence (AI)-based radiographic information versus standard radiographic and clinical information to dental students on their pulp exposure prediction ability.
Methods: 292 preoperative bitewing radiographs from patients previously treated were used. A multi-path neural network was implemented. The first path was a convolutional neural network (CNN) based on ResNet-50 architecture. The second path was a neural network trained on the distance between the pulp and lesion extracted from X-ray segmentations. Both paths merged and were followed by fully connected layers that predicted the probability of pulp exposure. A trial concerning the prediction of pulp exposure based on radiographic input and information on age and pain was conducted, involving 25 dental students. The data displayed was divided into 4 groups (G): G, G, G, G.
Results: The results showed that AI surpassed the performance of students in all groups with an F1-score of 0.71 (P < 0.001). The students' F1-score in G and G with model prediction (0.61 and 0.61 respectively) was slightly higher than the F1-score in G and G (0.58 and 0.59 respectively) with a borderline statistical significance of P = 0.054.
Conclusions: Although the AI model had much better performance than all groups, the participants when given AI prediction, benefited only 'slightly'. AI technology seems promising, but more explainable AI predictions along with a 'learning curve' are warranted.
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http://dx.doi.org/10.1016/j.jdent.2023.104732 | DOI Listing |
Biofabrication
January 2025
Polymer Chemistry and Biomaterials (PBM) Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, Gent, 9000, BELGIUM.
Volumetric bioprinting has revolutionized the field of biofabrication by enabling the creation of cubic centimeter-scale living constructs at faster printing times (in the order of seconds). However, a key challenge remains: developing a wider variety of available osteogenic bioinks that allow osteogenic maturation of the encapsulated cells within the construct. Herein, the bioink exploiting a step-growth mechanism (norbornene-norbornene functionalized gelatin in combination with thiolated gelatin - GelNBNBSH) outperformed the bioink exploiting a chain-growth mechanism (gelatin methacryloyl - GelMA), as the necessary photo-initiator concentration was three times lower combined with a more than 50 % reduction in required light exposure dose resulting in an improved positive and negative resolution.
View Article and Find Full Text PDFElife
January 2025
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Trained immunity (TI) is the process wherein innate immune cells gain functional memory upon exposure to specific ligands or pathogens, leading to augmented inflammatory responses and pathogen clearance upon secondary exposure. While the differentiation of hematopoietic stem cells (HSCs) and reprogramming of bone marrow (BM) progenitors are well-established mechanisms underpinning durable TI protection, remodeling of the cellular architecture within the tissue during TI remains underexplored. Here, we study the effects of peritoneal Bacillus Calmette-Guérin (BCG) administration to find TI-mediated protection in the spleen against a subsequent heterologous infection by the Gram-negative pathogen Typhimurium (.
View Article and Find Full Text PDFBraz J Microbiol
January 2025
Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP 14.404-600, Brazil.
Failures in endodontic treatments are common due to microbial resistance in the pulp canal. The study evaluated the in vitro activity of polyhexamethylene guanidine hydrochloride (PHMGH) against endodontic strains, as well as in vivo toxicity. Using minimum inhibitory concentration and minimum bactericidal concentration techniques, PHMGH was effective against all microorganisms, even at low concentrations.
View Article and Find Full Text PDFInt Endod J
January 2025
Department of Periodontics & Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, India.
Aim: The objective of pulpotomy is to preserve the pulp vitality. However, the assessment of pulpal status following pulpotomy is often overlooked. This retrospective analysis aimed to compare the pulp responses to EPT (Electric pulp test) and cold test in mature permanent molars that have undergone either complete pulpotomy (CP) or partial pulpotomy (PP) for managing carious pulpal exposure and symptomatic irreversible pulpitis (SIP) and completed 12 months follow-up.
View Article and Find Full Text PDFJ Transl Med
January 2025
Dental School, The University of Western Australia, 17 Monash Avenue, Nedlands, WA, 6009, Australia.
Background: Treatment of deep carious lesions poses significant challenges in dentistry, as complete lesion removal risks compromising pulp vitality, while selective removal often reduces the longevity of restorations. Herein, we propose a minimally invasive approach using High-Intensity Focused Ultrasound (HIFU) for microscale removal of carious dentine. Concurrently, HIFU's antimicrobial effects against associated cariogenic biofilms and the corresponding thermal and biological impacts on surrounding tissues were investigated.
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