Despite the broad use of helmets, incidence of concussion remains high. Current methods for helmet evaluation focus on the measurement of head kinematics as the primary tool for quantifying risk of brain injury. Though the primary cause of mild Traumatic Brain Injury (mTBI) is thought to be intracranial strain, helmet testing methodologies are not able to directly resolve these parameters. Computational injury models and impact severity measures are currently used to approximate intracranial strains from head kinematics and predict injury outcomes. Advancing new methodologies that enable experimental intracranial strain measurements in a physical model would be useful in the evaluation of helmet performance. This study presents a proof-of-concept head surrogate and novel helmet evaluation platform that allows for the measurement of intracranial strain using high-speed X-ray digital image correlation (XDIC). In the present work, the head surrogate was subjected to a series of bare and helmeted impacts using a pneumatically-driven linear impactor. Impacts were captured at 5,000 fps using a high-speed X-ray cineradiography system, and strain fields were computed using digital image correlation. This test platform, once validated, will open the door to using brain tissue-level measurements to evaluate helmet performance, providing a tool that can be translated to represent mTBI injury mechanisms, benefiting the helmet design processes.
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http://dx.doi.org/10.1016/j.jmbbm.2023.106140 | DOI Listing |
Zh Vopr Neirokhir Im N N Burdenko
December 2024
Burdenko Neurosurgical Center, Moscow, Russia.
Unlabelled: The development of new drugs in nuclear medicine for diagnosis or treatment (chemotherapy) of brain tumors, in particular gliomas, is inextricably linked with the use of tumor models in animals (usually rats).
Objective: To compare the widely used glioma cell model C6 and the new experimental tissue model of glioblastoma 101.8.
PLoS Pathog
December 2024
Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America.
In patients with synucleinopathies, the protein α-synuclein misfolds into multiple conformations, each of which determines whether a patient develops multiple system atrophy (MSA) or one of three Lewy body diseases (LBDs). However, patients may also first present with pure autonomic failure, which strictly impacts autonomic nerves in the periphery, which can then phenoconvert into MSA or a LBD. When neuroinvasion happens, it remains unknown if strain properties are retained or if strain adaptation occurs, even though neuroinvasion of some prion protein (PrP) strains is known to result in the emergence of novel PrP strain variants.
View Article and Find Full Text PDFNeurophotonics
January 2025
Washington University School of Medicine, Center for Neuroimmunology and Neuroinfectious Diseases, St. Louis, Missouri, United States.
Significance: Determining the long-term cognitive impact of infections is clinically challenging. Using functional cortical connectivity, we demonstrate that interhemispheric cortical connectivity is decreased in individuals with acute Zika virus (ZIKV) encephalitis. This correlates with decreased presynaptic terminals in the somatosensory cortex.
View Article and Find Full Text PDFSci Rep
November 2024
Gavin Herbert Eye Institute, University of California, Irvine, Irvine, CA, 92617, USA.
Rev Neurosci
November 2024
Department of Radiology, School of Medicine, 12474 Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, No. 600, Yishan Road, Shanghai, 200233, China.
Intracranial atherosclerotic disease (ICAD) significantly increases the risk of ischemic stroke. It involves the accumulation of plaque within arterial walls and narrowing or blockage of blood vessel lumens. Accurate imaging is crucial for the diagnosis and management of ICAD at both acute and chronic stages.
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