Background: The aim of this study was to determine the relationship between the severity of bladder functions, fatigue, quality of life (QoL), fall, and pelvic floor muscle strength in patients with Multiple Sclerosis (PwMS).
Methods: Patients were divided into two groups according to their Expanded Disability Status Scale (EDSS) bladder scores as Group 1 (EDSS bladder score 0-1, mildly affected group, n = 25) and Group 2 (EDSS bladder score 2-3-4, moderate and severely affected group, n = 21). Pelvic floor muscle (PFM) strength (EMG-Biofeedback device), fear of fall (Fall Efficacy Scale (FES-1)), fatigue (Fatigue Severity Scale (FSS)), QoL (Urogenital Distress Inventory-short form (UDI-6), and Incontinence Impact Questionnaire-short form (IIQ-7)) were evaluated.
Results: 46 female patients diagnosed with MS were included in this study. No significant differences in baseline characteristics were seen between the groups except age. EDSS bladder score were 1 (0-1) and 3 (2-4), EMG-Biofeedback score were 79,5 ± 8,11 and 41,7 ± 5,48, FSS score were 38,7 ± 2,80 and 54±2,20, FES-I score were 16,9 ± 2,15 and 40,2 ± 7,39, UDI-6 score were 4,24±0,47 and 8,42±0,64, IIQ-7 score were 3,64±0,86 and 18,2 ± 1,42 in Group 1 and Group 2. As a result of statistical analysis, significant differences were found in less fatigue and fall, higher PFM strength and better QoL with mildly affected PwMS (p<0,05).
Conclusion: There was a significant difference in terms of bladder function level in PFM strength, fall, fatigue and QoL between the mildly affected group and the moderate and severely affected group.
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http://dx.doi.org/10.1016/j.msard.2023.105013 | DOI Listing |
Front Immunol
January 2025
Department of Neurology, The Second Affiliated Hospital, Army Medical University, Chongqing, China.
Objective: To investigate the differences of clinical characteristics and treatment outcomes between paraneoplastic neurologic syndrome (PNS) patients with one high-risk antibody and patients with two high-risk antibodies.
Methods: We retrospectively analyzed the data of 51 PNS patients with high-risk antibody. Clinical data were extracted from the patients' electronic medical records.
Wiad Lek
December 2024
DEPARTMENT OF NEUROLOGY, FACULTY OF MEDICAL SCIENCES IN KATOWICE, MEDICAL UNIVERSITY OF SILESIA, KATOWICE, POLAND.
Objective: Aim: Bladder disorders are one of the most troubling symptoms of Multiple Sclerosis (MS), which impact patients quality of life (QoL). Therefore the aim of this pilot study was to assess this problem.
Patients And Methods: Materials and Methods: 47 patients (28 females and 19 males, aged 40,8±12,2 years; EDSS 3,2±1,9) diagnosed with Relapsing Remitting Multiple Sclerosis (RRMS) during disease modifying treatment (DMT) were enrolled to our study.
Fr J Urol
December 2024
GRC 01, GREEN Group of clinical REsEarch in Neurourology, Sorbonne University, Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
Purpose: This study aimed to assess the relationship between kinetics of bladder sensations perception, detrusor overactivity (DO), and severity of overactive bladder (OAB) symptoms in patients with multiple sclerosis (PwMS).
Methods: All PwMS who underwent urodynamic assessment including three cystometries (20mL/min, 100mL/min, and 100mL/min with 4°C fluid) between June 2020 and October 2022 were included in this retrospective study. Data collected were bladder diaries, symptoms assessed with Urinary Symptom Profile (USP), bladder sensations with first desire to void (FDV) and strong desire to void (SDV) during the 20mL/min cystometry, and presence of DO.
J Clin Neurol
November 2024
Second Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Ther Adv Neurol Disord
October 2024
Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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