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Mitral valve infective endocarditis as a manifestation of disseminated Cryptococcus neoformans infection: a case report.

Arch Peru Cardiol Cir Cardiovasc

December 2024

Departamento de Cardiología Clínica. Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Ciudad De México, Mexico. Departamento de Cardiología Clínica Instituto Nacional de Cardiología Ignacio Chávez Ciudad De México Mexico.

Infective endocarditis is a disease that affects mainly the endocardial surface of the heart and cardiac valves (native or prosthetic). The main risk factors for developing infective endocarditis are male sex, older age, intracardiac shunts, prosthetic valves, rheumatic, and congenital heart disease, intracardiac devices, intravenous drugs use, immunosuppression, and hemodialysis. Streptococci and Staphylococci spp.

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Background: Valvular heart disease (VHD) is a major focus of cardiovascular medicine, but limited data are available for racial and ethnic minorities. The aim was to assess the burden and clinical correlates of VHD in a highly diverse area of the United States.

Methods And Results: Individuals with echocardiographic diagnosis of native VHD between January 2010 and December 2019 at a quaternary care health system of the Bronx (New York, USA) were included.

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Submitral aneurysm is a challenging and uncommon cardiac disease that is uniquely related to the posterior mitral valve leaflet. Awareness and prompt identification are vital because of the strong predilection for sudden fatal complications. Techniques and timing of surgical procedures are not standardized, especially in incidentally detected cases.

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A 33-year-old woman who had previously undergone mitral valve repair for native valve endocarditis presented with a submitral left ventricular pseudoaneurysm, with related mitral valve dysfunction. The operative approach to this complex pathophysiologic process is presented.

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From the INVICTUS Trial to Current Considerations: It's Not Time to Retire Vitamin K Inhibitors Yet!

Pharmaceuticals (Basel)

October 2024

Division of Cardiology and CardioLab, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Article Synopsis
  • Atrial fibrillation (AF) is common and usually treated with oral anticoagulants to prevent strokes, where direct oral anticoagulants (DOAC) are more effective in reducing certain types of bleeding compared to vitamin K antagonists (VKA).
  • The INVICTUS study showed that the DOAC rivaroxaban was not superior to VKA in preventing serious complications like stroke for patients with rheumatic valvular AF, leading to higher death and drug discontinuation rates in the DOAC group.
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