AI Article Synopsis
- Post-translational modifications (PTMs) of proteins, including both canonical (like ubiquitination, glycosylation, and phosphorylation) and non-canonical types, play significant roles in the development of gastrointestinal tumors.
- Recent research highlights that non-canonical PTMs such as sumoylation, neddylation, isoprenylation, and succinylation are crucial for tumor formation, metastasis, and treatment outcomes.
- Targeting these specific PTMs may enhance treatment strategies and improve the prognosis for patients with gastrointestinal tumors.
Article Abstract
Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently, emerging evidence showed that non-canonical PTMs play an essential role in the carcinogenesis, metastasis and treatment of gastrointestinal tumors. Therefore, we summarized recent advances in sumoylation, neddylation, isoprenylation, succinylation and other non-canonical PTMs in gastrointestinal tumors, which comprehensively describe the mechanisms and functions of non-classical PTMs in gastrointestinal tumors. It is anticipated that targeting specific PTMs could benefit the treatment as well as improve the prognosis of gastrointestinal tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544213 | PMC |
| http://dx.doi.org/10.1186/s12935-023-03062-x | DOI Listing |
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