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Aggregating multiple test results to improve medical decision-making.
PLoS Comput Biol
January 2025
Department of Computational Medicine, University of California, Los Angeles, Los Angeles, California, United States of America.
Gathering observational data for medical decision-making often involves uncertainties arising from both type I (false positive) and type II (false negative) errors. In this work, we develop a statistical model to study how medical decision-making can be improved by aggregating results from repeated diagnostic and screening tests. Our approach is relevant to not only clinical settings such as medical imaging, but also to public health, as highlighted by the need for rapid, cost-effective testing methods during the SARS-CoV-2 pandemic.
View Article and Find Full Text PDFThe role of a vaccine booster for a fractional order model of the dynamic of COVID-19: a case study in Thailand.
Sci Rep
January 2025
Department of Applied Basic Subjects, Thatphanom College, Nakhon Phanom University, Nakhon Phanom, 48000, Thailand.
This article addresses the critical need for understanding the dynamics of COVID-19 transmission and the role of booster vaccinations in managing the pandemic. Despite widespread vaccination efforts, the emergence of new variants and the waning of immunity over time necessitate more effective strategies. A fractional-order mathematical model using Caputo-Fabrizio derivatives was developed to analyze the impact of booster doses, symptomatic and asymptomatic infections, and quarantine measures.
View Article and Find Full Text PDFHydrogel-Gated MXene-Graphene Field-Effect Transistor for Selective Detection and Screening of SARS-CoV-2 and Bacteria.
ACS Appl Mater Interfaces
January 2025
Zachry Department of Civil and Environmental Engineering, Texas A&M University, College Station, Texas 77843, United States.
Field-effect transistor (FET) biosensors have significantly attracted interest across various disciplines because of their high sensitivity, time-saving, and label-free characteristics. However, it remains a grand challenge to interface the FET biosensor with complex liquid media. Unlike standard liquid electrolytes containing purified protein content, directly exposing FET biosensors to complex biological fluids introduces significant sensing noise, which is caused by the abundance of nonspecific proteins, viruses, and bacteria that adsorb to the biosensor surfaces.
View Article and Find Full Text PDFCardiac Damage in Patients Infected with Different SARS-CoV-2 Variants of Concern.
Microorganisms
December 2024
Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Coronavirus Disease 2019 causes significant morbidity, and different variants of concern (VOCs) can impact organ systems differently. We conducted a single-center retrospective cohort analysis comparing biomarkers and clinical outcomes in hospitalized patients infected with the wild-type or Alpha (wt/Alpha) VOC against patients infected with the Omicron VOC. We included 428 patients infected with the wt/Alpha VOC and 117 patients infected with the Omicron VOC.
View Article and Find Full Text PDFRapid In-Field Detection of Airborne Pathogens Using Loop-Mediated Isothermal Amplification (LAMP).
Microorganisms
December 2024
School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK.
Multiple human and plant pathogens are dispersed and transmitted as bioaerosols (e.g., , SARS-CoV-2, , , spp.
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