Groundwater in arid and semi-arid coastal aquifers is vulnerable to seawater intrusion and quality deterioration despite being one of the most reliable sources of water supply due to the increasing number of development plans and competition between water consumers. A multi-dimensional groundwater management framework is developed to trade-off between groundwater abstraction, allocation equity, groundwater quality, and energy considerations in the reverse osmosis (RO) filtration process in the fresh groundwater lens of Kish Island, Iran. An arid island confined in the Persian Gulf is modeled using 3D simulation and three well-occupied multi-objective evolutionary optimization algorithms. Four objectives include: maximizing the groundwater abstraction, minimizing the Gini coefficient (allocation inequity), minimizing the total energy required to pass saline water through the RO membrane to reach the standard total dissolved solids (TDS), and minimizing the average TDS concentration of water abstraction positions from 11 management zones have been considered over a 50-year management horizon. Solutions obtained in the simulation-based constrained multi-objective optimization framework allow managers to choose from 587 Pareto optimal solutions. They provide an abstraction scheme with a range of 1.44 to 4.53 MCM/yr, a Gini coefficient of 0 to 0.98, filtration energy of 988,562 to 1,935,760 kWh/yr, and an average TDS of 19,663 to 21,351 mg/L. The Pareto optimal solutions can help decision-makers decide on the multi-dimensional problems of sustainable coastal groundwater management and show patterns among different objectives.
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http://dx.doi.org/10.1016/j.jenvman.2023.119032 | DOI Listing |
Alzheimers Dement
December 2024
Critical Path for Alzheimer's Disease (CPAD) Consortium, Critical Path institute, Tucson, AZ, USA.
Background: To help improve the Alzheimer's disease (AD) therapeutics research and development process, the Critical Path for Alzheimer's Disease (CPAD) Consortium at the Critical Path Institute (C-Path) provides a neutral framework for the drug development industry, regulatory agencies, academia, and patient advocacy organizations to collaborate. CPAD's extensive track record of developing regulatory-grade quantitative drug development tools motivates sponsors to share patient-level data and neuroimages from clinical trials. CPAD leverages these data and uses C-Path's core competencies in data management and standardization, quantitative modeling, and regulatory science to develop tools that help de-risk decision making in AD drug development.
View Article and Find Full Text PDFBackground: Dementia is a life-changing condition for patients and caregivers. Response to a diagnosis often includes grief, shock, and despair. Unfortunately, evidence demonstrates inadequate use of person-centered communication practices during diagnostic disclosure, which adds to psychological distress.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
College of Medicine, University of Ibadan, Ibadan, Nigeria.
Background: Limited knowledge exists about the cultural approaches to managing the psychological and behavioral outcomes (PBO) of Alzheimer's Disease and Alzheimer's Disease-Related Dementia (AD/ADRD) in Africa. Specifically, to develop a culture-sensitive training framework for AD/ADRD caregivers, we explored AD/ADRD caregivers' cultural embeddedness in managing people living with AD/ADRD (PLWAD/ADRD) in Ibadan, Nigeria.
Method: Using hermeneutic phenomenological qualitative research design, we interviewed 23 caregivers providing care to PLWAD/ADRD in Ibadan, a Yoruba-speaking ethnic group of Nigeria.
Alzheimers Dement
December 2024
New York University, New York, NY, USA.
Background: Adults with comorbidity of cognitive impairment and diabetes is common (19.9%-45.0%) and increasing; however, the evidence is lacking on non-pharmacological behavioral interventions to support cognitive health and diabetes management for individuals with both conditions.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Despite an increasing prevalence of Alzheimer's disease and related dementias among Black older adults, large disparities remain in early diagnosis, treatment, and support service referral. Further, services intended to support family caregivers are typically designed around older adult spousal caregivers with little consideration to the wide diversity of families affected by dementia. This qualitative descriptive study examined the caregiving experiences of Black relatives of persons with dementia with the aim of informing the development of more culturally responsive support programming.
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