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Substrate stiffness modulates extracellular vesicles' release in a triple-negative breast cancer model.
Extracell Vesicles Circ Nucl Acids
September 2024
Nano-Innovation Laboratory, Elettra-Sincrotrone Trieste S.C.p.A., Trieste 34149, Italy.
Aim: The microenvironment effect on the tumoral-derived Extracellular Vesicle release, which is of significant interest for biomedical applications, still represents a rather unexplored field. The aim of the present work is to investigate the interrelation between extracellular matrix (ECM) stiffness and the release of small EVs from cancer cells. Here, we focus on the interrelation between the ECM and small extracellular vesicles (sEVs), specifically investigating the unexplored aspect of the influence of ECM stiffness on the release of sEVs.
View Article and Find Full Text PDF[Development of research on mechanisms of acupuncture intervention on ischemic stroke and its relationship with microglia].
Zhen Ci Yan Jiu
December 2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine, Acupuncture and Moxibustion, Tianjin 300381.
Microglia, the main phagocytic cells in the brain, play a key role in inflammatory response and neuroprotection in ischemic stroke, and are potential targets for the treatment of ischemic stroke. Multiple studies have confirmed that the effect of acupuncture on ischemic stroke is closely related to its effect in regulating the activities of microglia. In the present paper, we reviewed the role of microglia in ischemic stroke and the current research status of acupuncture intervention, and prospects the future research direction.
View Article and Find Full Text PDFChondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids.
Chembiochem
November 2024
Department of Chemistry, University of Turku, 20500, Turku, Finland.
Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide the oligonucleotide content and simultaneously enhance the role of appropriate conjugate groups on the outer sphere. The conjugate halo may be modulated to affect the delivery properties of the MSNAs.
View Article and Find Full Text PDFEvaluation of aneurysm flow divertor (stent) treatment using multi-angled 1000 fps High-Speed Angiography (HSA) and Optical Flow (OF).
Proc SPIE Int Soc Opt Eng
February 2024
University of Buffalo, Buffalo, New York, USA; Canon Research Stroke and Vascular Center, Buffalo, New York, USA; Florida Institute of Technology, Melbourne, Florida.
Understanding detailed hemodynamics is critical in the treatment of aneurysms and other vascular diseases; however, traditional digital subtraction angiography (DSA) does not provide detailed quantitative flow information. Instead, 1000 fps High-Speed Angiography (HSA) can be used for high-temporal visualization and evaluation of detailed blood flow patterns and velocity distributions. In the treatment of aneurysms, flow diverter expansion and positioning play a critical role in affecting the hemodynamics and optimal patient outcomes.
View Article and Find Full Text PDFIsolation and quantification of human urinary exosomes using a Tween-20 elution solvent from polyester, capillary-channeled polymer fiber columns.
Anal Chim Acta
November 2024
Department of Chemistry, Biosystems Research Complex, Clemson University, Clemson, SC, 29634-0973, USA. Electronic address:
Article Synopsis
- Exosomes are crucial for cell communication and have potential roles in therapy, making their isolation and quantification important for research.
- This study evaluates Tween-20 as an elution solvent for exosome recovery, demonstrating its effectiveness in isolating high-purity exosomes quickly.
- The new method incorporates advanced detection techniques, ensuring accurate measurement of exosome concentration and size, which can benefit various fields like clinical diagnostics and biochemistry.
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