AI Article Synopsis
- - Takayasu arteritis (TAK) is a complex condition with no reliable biomarkers, prompting a study on associated factor panels and their response to biologic treatments.
- - Five distinct factor panels were identified: systemic inflammation, vascular inflammation, immune regulation, angiogenesis and fibrosis, and vascular remodeling, with key insights into how they relate to disease activity and ischemic cases.
- - Following treatment, tocilizumab effectively reduced several inflammatory markers, while adalimumab increased levels of specific factors, providing new insights for more targeted future therapies in TAK.
Article Abstract
Takayasu arteritis (TAK) is complicated disorder without reliable biomarkers. Here, we aimed to explore TAK-associated factor panels and their changes after biologic treatment. Five factor panels were identified: 1. systemic inflammation: C3, ESR, CRP, PLT, IL-6, C4, and IgG; 2. vascular inflammation: YKL40, IL-16, PTX3, and CCL2; 3. immune regulation panel: IL-10, IFN-γ, CCL5, and MMP1; 4. angiogenesis and fibrosis: FGF, PDGFAB, and VEGF; and 5. vascular remodeling: CD19+ B cell ratio, MMP3, and leptin. Panel 1 parameters were closely related to disease activity, while Panel 5 parameters, particularly CD19+ B cell ratio and leptin, were significantly higher in ischemic patients. After treatment, tocilizumab had a stronger inhibitory effect on Panel 1 parameters, PTX3, and YKL-40, while adalimumab led to an increase in IL-16, CCL2, and leptin levels. Altogether, these data expanded our knowledge regarding molecular background in TAK development and shed light on precise treatment in future studies.
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| http://dx.doi.org/10.1016/j.clim.2023.109794 | DOI Listing |
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