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Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis.
Nature
January 2025
Department of Biological Sciences, The University of Tokyo, Tokyo, Japan.
In organisms ranging from vertebrates to plants, major components of centromeres are rapidly evolving repeat sequences, such as tandem repeats (TRs) and transposable elements (TEs), which harbour centromere-specific histone H3 (CENH3). Complete centromere structures recently determined in human and Arabidopsis suggest frequent integration and purging of retrotransposons within the TR regions of centromeres. Despite the high impact of 'centrophilic' retrotransposons on the paradox of rapid centromere evolution, the mechanisms involved in centromere targeting remain poorly understood in any organism.
View Article and Find Full Text PDFA Drosophila Model of Mucopolysaccharidosis IIIB.
Genetics
December 2024
Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, 114 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare lysosomal storage disorder caused by defects in alpha-N-acetylglucosaminidase (NAGLU) and characterized by severe effects in the central nervous system. Mutations in NAGLU cause accumulation of partially degraded heparan sulfate in lysosomes. The consequences of these mutations on whole genome gene expression and their causal relationships to neural degeneration remain unknown.
View Article and Find Full Text PDFTemporal dynamics in a red alga dominated geothermal feature in Yellowstone National Park.
ISME Commun
January 2024
Department of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States.
Alga-dominated geothermal spring communities in Yellowstone National Park (YNP), USA, have been the focus of many studies, however, relatively little is known about the composition and community interactions which underpin these ecosystems. Our goal was to determine, in three neighboring yet distinct environments in Lemonade Creek, YNP, how cells cope with abiotic stressors over the diurnal cycle. All three environments are colonized by two photosynthetic lineages, and , both of which are extremophilic Cyanidiophyceae red algae.
View Article and Find Full Text PDFAmide conjugates of the jasmonate precursor cis-(+)-12-oxo-phytodienoic acid regulate its homeostasis during plant stress responses.
Plant Physiol
December 2024
Laboratory of Growth Regulators, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-77900, Czech Republic.
Jasmonates are a family of oxylipin phytohormones regulating plant development and growth and mediating "defense versus growth" responses. The upstream JA biosynthetic precursor cis-(+)-12-oxo-phytodienoic acid (cis-OPDA) acts independently of CORONATIVE INSENSITIVE 1-mediated JA signaling in several stress-induced and developmental processes. However, its perception and metabolism are only partially understood.
View Article and Find Full Text PDFPhenoMetaboDiff: R Package for Analysis and Visualization of Phenotype Microarray Data.
Genes (Basel)
October 2024
JC Self Research Institute, 106 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Article Synopsis
- PhenoMetaboDiff is an innovative R package designed for analyzing and visualizing data from Biolog Phenotype Mammalian Microarrays, which study the energy production of mammalian cells under various conditions.* -
- It provides non-parametric statistical methods, integrates with the OPM package for file conversion, calculates performance metrics like slope and area under the curve, and includes visualization tools to analyze specific metabolic pathways.* -
- This package enhances the assessment of metabolic profiles and is user-friendly, making advanced analysis accessible for both experienced and beginner R users, ultimately benefiting research in various disease conditions.*
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