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Dietary Intake of Micronutrients and Use of Vitamin and/or Mineral Supplements: Brazilian National Food Survey.
Nutrients
November 2024
Postgraduate Program in Epidemiology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-190, Rio Grande do Sul, Brazil.
Background/objectives: Vitamin and/or mineral supplements are designed to correct micronutrient deficiencies or maintain adequate intake. However, evidence suggests the indiscriminate use of these products, particularly among populations that already meet their micronutrient requirements through diet. This study aims to estimate the prevalence of vitamin and/or mineral supplement use and assess the dietary intake of micronutrients among users and non-users in the Brazilian adult and elderly populations.
View Article and Find Full Text PDFRhinoceros horn mineral and metal concentrations vary by sample location, depth, and color.
Sci Rep
June 2024
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Rd, Lansing, MI, 489100, USA.
Poaching is again driving rhinos to the brink of extinction due to the demand for rhino horn products consumed for cultural, medicinal, and social purposes. Paradoxically, the same horn for which rhinos are killed may contain valuable clues about the species' health. Analyses of horn composition could reveal such useful bioindicators while elucidating what people actually ingest when they consume horn derivatives.
View Article and Find Full Text PDFNeurological Deterioration in Wilson's Disease-Types, Etiology, Course, and Management.
Discov Med
April 2024
Second Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.
Wilson's disease (WD) is an inherited disorder of copper metabolism in which pathological copper accumulation, mainly in the liver and the brain, leads to hepatic and/or neuropsychiatric signs and symptoms. Chelators and zinc salts can successfully induce negative copper balance in many patients; however, neurological deterioration may still be observed. This phenomenon can be divided into: (1) early 'paradoxical' neurological deterioration, which usually develops in the first 6 months of anti-copper treatment and may be commonly related to drug type, or (2) late neurological deterioration, which mostly occurs after 6 months of treatment and is often related either to non-compliance with treatment, overtreatment resulting in copper deficiency, or adverse drug reactions.
View Article and Find Full Text PDFImpact of antioxidants on PM oxidative potential, radical level, and cytotoxicity.
Sci Total Environ
February 2024
Shenzhen Key Laboratory of Precision Measurement and Early Warning Technology for Urban Environmental Health Risks, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; Guangdong Provincial Observation and Research Station for Coastal Atmosphere and Climate of the Greater Bay Area, Shenzhen 518055, China.
Antioxidants are typically seen as agents that mitigate environmental health risks due to their ability to scavenge free radicals. However, our research presents a paradox where these molecules, particularly those within lung fluid, act as prooxidants in the presence of airborne particulate matter (PM), thus enhancing PM oxidative potential (OP). In our study, we examined a range of antioxidants found in the respiratory system (e.
View Article and Find Full Text PDFEffects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease.
J Hepatol
April 2024
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Background & Aims: In Wilson disease (WD), copper accumulates in the liver and brain causing disease. Bis-choline tetrathiomolybdate (TTM) is a potent copper chelator that may be associated with a lower risk of inducing paradoxical neurological worsening than conventional therapy for neurologic WD. To better understand the mode of action of TTM, we investigated its effects on copper absorption and biliary excretion.
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