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Navigating access to medical gender affirmation in Tasmania, Australia: an exploratory study.
Int J Transgend Health
November 2023
School of Social Sciences, University of Tasmania, Hobart, Tasmania, Australia.
Article Synopsis
- Gender affirmation through hormone therapies and surgery greatly enhances the wellbeing of transgender, nonbinary, and gender diverse individuals, but many still encounter significant barriers, especially in rural areas.
- A study conducted in Tasmania surveyed 84 trans and gender diverse residents to identify these barriers, revealing that financial issues, geographical obstacles, discrimination, and medical gatekeeping were the main challenges faced.
- The article suggests that adopting a model of gender affirmation based on informed consent could help alleviate these barriers and improve overall health outcomes for these individuals.
QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction.
Nat Commun
September 2024
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Article Synopsis
- * QSOX2 is crucial for the proper functioning of Growth hormone by facilitating the transit of a signaling protein (STAT5B) into the nucleus, and its deficiency leads to impaired cellular processes and multi-system issues.
- * The findings suggest that using recombinant insulin-like growth factor-1 could help address the problems caused by the defective QSOX2 gene, potentially improving organ-specific health outcomes.
SIK2 Controls the Homeostatic Character of the POMC Secretome Acutely in Response to Pharmacological ER Stress Induction.
Cells
September 2024
Department of Molecular Biology and Genetics, Graduate School of Natural and Applied Sciences, Gebze Technical University (GTU), Gebze, Kocaeli 41400, Turkey.
The neuronal etiology of obesity is centered around a diet-induced inflammatory state in the arcuate nucleus of the hypothalamus, which impairs the functionality of pro-opiomelanocortine neurons (POMCs) responsible for whole-body energy homeostasis and feeding behavior. Intriguingly, systemic salt inducible kinase 2 (SIK2) knockout mice demonstrated reduced food intake and energy expenditure along with modestly dysregulated metabolic parameters, suggesting a causal link between the absence of SIK2 activity in POMCs and the observed phenotype. To test this hypothesis, we conducted a comparative secretomics study from POMC neurons following pharmacologically induced endoplasmic reticulum (ER) stress induction, a hallmark of metabolic inflammation and POMC dysregulation in diet-induced obese (DIO) mice.
View Article and Find Full Text PDFTanycytes from a bird's eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmigan.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
September 2024
Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology & Physiology, Arctic & Marine Biology, BFE, UiT - Arctic University of Norway, Tromsø, Norway.
In mammals and birds, tanycytes are known to regulate thyroid hormone conversion, and this process is central to the control of seasonal reproduction. In mammals, this cell type is also implicated in retinoic acid signalling, neurogenesis, and nutritional gatekeeping, all of which have been linked to hypothalamic regulation of energy metabolism. Less is known about these potential wider roles of tanycytes in birds.
View Article and Find Full Text PDFVolatile organic compound exposure in relation to lung cancer: Insights into mechanisms of action through metabolomics.
J Hazard Mater
December 2024
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
Volatile organic compounds (VOCs) have proven to be hazardous to the human respiratory system. However, the underlying biological mechanisms remain poorly understood. Therefore, targeted determination of eleven VOC metabolites (mVOCs) along with the nontargeted metabolomic analysis was performed on urine samples collected from lung cancer patients and healthy individuals.
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