A stochastic alternative technique for Compton Maximum Likelihood Expectation-Maximization (MLEM) reconstruction.

Comput Biol Med

Department of Physics, National and Kapodistrian University of Athens, Greece; Institute of Accelerating Systems & Applications (IASA), Athens, Greece. Electronic address:

Published: November 2023

Even though iterative methods and particularly Maximum Likelihood Expectation-Maximization (MLEM) algorithms have been established in reconstruction with Compton data, their detailed design with respect to physical rules and processes dominate their plain implementation in the form of a system matrix. A new elementary but efficient alternative for the well-known system matrix with respect to Compton Camera image reconstruction is presented in this work. For each detected event there is a weighting factor inserted as an accumulated probability which carries all the necessary information. This probability which involves only the Compton scattering angle of the incident photon corresponds to a map that correlates all events within all possible source origins. Based on maximizing likelihood principles, the proposed model weights in a stochastic way the difference of the scatterer-to-source angle θ, as it is determined by the deposited energy on the absorber, and any other potential scattering angle θ, specified by the position coordinates on the reconstruction matrix. Obtained image spatial resolution, angular distortions and response to focal length determination are a few of the studied cases for the algorithms' evaluation via simulations in GEANT4/GATE with a set of radioactive sources and phantoms with in- and out-of-plane arrangement.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2023.107502DOI Listing

Publication Analysis

Top Keywords

maximum likelihood
8
likelihood expectation-maximization
8
expectation-maximization mlem
8
system matrix
8
scattering angle
8
stochastic alternative
4
alternative technique
4
compton
4
technique compton
4
compton maximum
4

Similar Publications

Background: Underdiagnosis of Alzheimer's disease and related dementias (ADRD) leads to lost opportunities for timely intervention, increased healthcare costs, and underestimation of the true burden of disease. To address this problem, we developed an AI algorithm, Decipher-AI (DEtection of Cognitive Impairment PHenotypes in EHR), to screen primary care patients for undiagnosed cognitive impairment (CI). We evaluated performance across sociodemographic groups using 3 years of EHR data before the first diagnosis or most recent visit.

View Article and Find Full Text PDF

Background: Underdiagnosis of Alzheimer's disease and related dementias (ADRD) leads to lost opportunities for timely intervention, increased healthcare costs, and underestimation of the true burden of disease. To address this problem, we developed an AI algorithm, Decipher-AI (DEtection of Cognitive Impairment PHenotypes in EHR), to screen primary care patients for undiagnosed cognitive impairment (CI). We evaluated performance across sociodemographic groups using 3 years of EHR data before the first diagnosis or most recent visit.

View Article and Find Full Text PDF

[Risk factors for mortality in patients with spontaneous cerebellar hemorrhage based on Mimics software analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue

December 2024

Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Corresponding author: Liu Zhenning, Email:

Objective: To investigate the independent risk factors for short-term mortality in patients with spontaneous cerebellar hemorrhage (SCH) based on Mimics software of medical image control system.

Methods: The clinical data of SCH patients treated at Shengjing Hospital of China Medical University from January, 2010 to December, 2021 was retrospectively analyzed and compared, including gender, age, underlyin g diseases, Glasgow coma scale (GCS) and blood pressure at admission, laboratory indicators, imaging data, and short-term (3 weeks after onset) survival status. The imaging examination parameters were accurately calculated using Mimics software, including hematoma volume, longest diameter, and maximum cross-sectional area of cerebellar hemorrhage.

View Article and Find Full Text PDF

Background: Despite its obvious relevance for clinical practice and research, it is surprising that presently no hope measure is available for use among Arabic-speaking populations, especially the most vulnerable ones who have been going through major humanitarian crises. This paper aimed to provide novel insights into psychometric information on the psychometric properties of an Arabic translation of the Perceived Hope Scale (PHS) in Palestinians living in Gaza who have endured several months of suffering since the war began in October 2023.

Method: This study had a cross-sectional design and applied a quantitative research approach.

View Article and Find Full Text PDF

The role of the left primary motor cortex in apraxia.

Neurol Res Pract

January 2025

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Background: Apraxia is a motor-cognitive disorder that primary sensorimotor deficits cannot solely explain. Previous research in stroke patients has focused on damage to the fronto-parietal praxis networks in the left hemisphere (LH) as the cause of apraxic deficits. In contrast, the potential role of the (left) primary motor cortex (M1) has largely been neglected.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!