Unsupervised domain adaptation (UDA) and domain generalization (DG) enable machine learning models trained on a source domain to perform well on unlabeled or even unseen target domains. As previous UDA&DG semantic segmentation methods are mostly based on outdated networks, we benchmark more recent architectures, reveal the potential of Transformers, and design the DAFormer network tailored for UDA&DG. It is enabled by three training strategies to avoid overfitting to the source domain: While (1) Rare Class Sampling mitigates the bias toward common source domain classes, (2) a Thing-Class ImageNet Feature Distance and (3) a learning rate warmup promote feature transfer from ImageNet pretraining. As UDA&DG are usually GPU memory intensive, most previous methods downscale or crop images. However, low-resolution predictions often fail to preserve fine details while models trained with cropped images fall short in capturing long-range, domain-robust context information. Therefore, we propose HRDA, a multi-resolution framework for UDA&DG, that combines the strengths of small high-resolution crops to preserve fine segmentation details and large low-resolution crops to capture long-range context dependencies with a learned scale attention. DAFormer and HRDA significantly improve the state-of-the-art UDA&DG by more than 10 mIoU on 5 different benchmarks.
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http://dx.doi.org/10.1109/TPAMI.2023.3320613 | DOI Listing |
BMC Health Serv Res
January 2025
College of Pharmacy, Gyeongsang National University, 501 Jinju-Daero, Jinju, 52828, Republic of Korea.
Background: Innovative health technologies have increasingly emerged as a promising solution for patients with untreatable or challenging conditions. However, these technologies often come with expensive costs and limited evidence at the time of launch. This study assessed how these high-priced drugs with limited evidence were appraised and introduced in South Korea, England, Australia, and Canada, where cost-effectiveness analysis (CEA) generally plays a central role in pricing and reimbursement decisions.
View Article and Find Full Text PDFBMC Psychiatry
January 2025
School of Nursing, Hangzhou Normal University, Hangzhou, 311121, China.
Objective: In recent years, there has been a rapid increase in reports upon social-cognition impairments in bipolar disorder. This study aimed to compare the characteristics of social cognition domains in bipolar I (BD I) and II (BD II) based on the findings to date.
Methods: A systematic literature search was conducted on Web of Science and PubMed from inception to 28 August 2024.
Adv Physiol Educ
January 2025
Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, Brazil.
This article explores an innovative educational approach using a metabolic board designed to enhance understanding of muscle metabolism across three endurance training zones: Z1 (light intensity), Z2 (moderate intensity), and Z3 (intense/severe intensity). The aerobic threshold marks the transition from light to moderate domains, and the anaerobic threshold separates moderate from intense domains, with both thresholds adapting to training. Exercises within each training zone elicit specific adaptive responses through distinct signaling pathways, but the metabolic profile induced remains relatively constant across these intensity domains.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Department of Pharmacology, Republic of Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 440-746, Republic of Korea; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, Republic of Korea. Electronic address:
ZNF398/ZER6 belongs to the Krüppel-associated box (KRAB) domain-containing zinc finger proteins (K-ZNFs), the largest family of transcriptional repressors in higher organisms. ZER6 exists in two isoforms, p52 and p71, generated through alternative splicing. Our investigation revealed that p71-ZER6 is abundantly expressed in the stomach, kidney, liver, heart, and brown adipose tissue, while p52-ZER6 is predominantly found in the stomach and brain.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:
The COVID-19 pandemic has underscored the urgent need for antiviral agents capable of targeting a broad range of coronaviruses, including emerging variants of SARS-CoV-2. While vaccines have been pivotal, the search for drugs that can prevent viral entry into host cells remains crucial, especially against evolving viral forms and other coronaviruses. In this study, we investigated natural products as a source of antiviral agents, focusing on their potential to block the spike protein's receptor-binding domain (RBD).
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