AI Article Synopsis
- - A 2D achiral metal-organic framework (IMU-MOF) was created using a solvothermal method to help distinguish chiral antimalarial drugs, quinine (QN) and quinidine (QD), which are crucial for health.
- - IMU-MOF acts as an ultrasensitive fluorescent probe, achieving detection limits for QN and QD at 4.24 × 10⁻¹⁰ M and 7.54 × 10⁻¹⁰ M, respectively.
- - Enhanced fluorescence in IMU-MOF is attributed to strong hydrogen-bonding interactions with quinine, leading to more efficient energy transfer during the sensing process.
Article Abstract
The effective discrimination and determination of the chiral antimalarial drugs quinine (QN) and quinidine (QD) are extremely important for human health. Herein, a 2D achiral Sm-based metal-organic framework (IMU-MOF = [Sm(tpba)(L)], where Htpba = 4-(2,2':6″,2'-terpyridin)-4'-ylbenzioc acid and HL = 2,2'-biquinoline-4,4'-dicarboxylic acid) was successfully prepared by the solvothermal method. More importantly, IMU-MOF was designed as an ultrasensitive fluorescent probe for the identification of chiral enantiomer drugs. The limits of detection for QN and QD are 4.24 × 10 and 7.54 × 10 M, respectively. Furthermore, it was demonstrated that the stronger hydrogen-bonding interactions between IMU-MOF and quinine furnish a more efficient energy transfer to the ligands in the sensing process, resulting in a significant fluorescence enhancement of IMU-MOF.
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| http://dx.doi.org/10.1021/acs.inorgchem.3c02333 | DOI Listing |
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