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Platelet-Rich Fibrin in Oral Surgery and Implantology: A Narrative Review. | LitMetric

Platelet-Rich Fibrin in Oral Surgery and Implantology: A Narrative Review.

Transfus Med Hemother

Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.

Published: August 2023

AI Article Synopsis

  • The use of platelet-rich fibrin (PRF) in dentistry is gaining traction due to its high growth factor content, low cost, and simple production method.
  • A review of 34 studies reveals PRF's effectiveness in procedures like wisdom tooth extractions, guided bone regeneration, and sinus floor elevation, though data on its role in osteonecrosis of the jaw remains limited.
  • While most studies show positive outcomes with PRF, particularly in intrabony defects, there's insufficient evidence regarding its benefits when used with bone grafts during sinus procedures.

Article Abstract

Background: The application of blood concentrates has gained popularity in dentistry in recent years. Platelet-rich fibrin (PRF) has been discussed frequently due to a high content of growth factors and the option of chair-side manufacturing in a simple centrifugation process. PRF is free from adjuvants and inexpensive to produce. The number of studies reporting beneficial effects of PRF in various clinical applications such as alveolar ridge preservation, sinus floor elevation, management and prevention of medical-related osteonecrosis of the jaw, third molar extractions, and guided bone regeneration in dentistry has increased recently. However, to date, neither clinical recommendations nor guidelines are available. The present narrative review aims to summarize the level of evidence on the clinical application of PRF within the field of oral surgery and implantology.

Summary: A literature search in Pubmed and Medline has identified 34 articles as a basis for this narrative review. The effectiveness of the clinical application of PRF has been analyzed for five indications within dentistry: medical-related osteonecrosis of the jaw, wisdom tooth extraction, guided bone regeneration, sinus floor elevation, and alveolar ridge preservation. The amount of data for third molar extractions, socket preservation, and guided bone regeneration is extensive. Less data were available for the use of PRF in combination with sinus floor elevations. There is a lack of studies with scientific evidence on PRF and medical-related osteonecrosis of the jaw; however, studies positively impact patient-related outcome measures. Most studies report on beneficial effects when PRF is additionally applied in intrabony defects. There is no evidence of the positive effects of PRF combined with bone graft materials during sinus floor elevation. However, some benefits are reported with PRF as a sole filling material.

Key Messages: Many recently published studies show the positive clinical impact of PRF. Yet, further research is needed to ensure the validity of the evidence.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521222PMC
http://dx.doi.org/10.1159/000527526DOI Listing

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