AI Article Synopsis
- Thermosensitive liposomes can enhance drug delivery to solid tumors, especially when used with mild hyperthermia.
- Our team created a thermosensitive liposome formulation for alvespimycin, intended to work alongside a similar formulation of doxorubicin (ThermoDXR), leading to a synergistic effect in breast cancer cell lines.
- The research further investigates the combination of doxorubicin and alvespimycin in mouse models, demonstrating its effectiveness in both immunocompromised and immunocompetent breast cancer scenarios.
Article Abstract
Thermosensitive liposomes in combination with localized mild hyperthermia can improve the delivery of drug to solid tumor sites. For this reason, thermosensitive liposome formulations of a range of chemotherapy drugs have been designed. Our group previously developed and characterized a thermosensitive liposome formulation of the heat shock protein 90 inhibitor alvespimycin as a companion therapeutic to a thermosensitive liposome formulation equivalent in composition to ThermoDox (i.e., ThermoDXR), with the goal of increasing the therapeutic index of doxorubicin as the combination was revealed to be highly synergistic in a panel of human breast cancer cell lines including MDA-MB-231 (Dunne et al., 2019). The data presented here further describes the effect of the doxorubicin (DXR) and alvespimycin (ALV) combination and . Specifically, the combination effect in mouse breast cancer 4T1 cells and the efficacy of this heat-activated chemotherapy combination in both immunocompromised (MDA-MB-231 tumor bearing female SCID mice) and immunocompetent (4T1 tumor bearing female BALB/c mice) models of breast cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519820 | PMC |
| http://dx.doi.org/10.1016/j.dib.2023.109545 | DOI Listing |
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