AI Article Synopsis
- The study aimed to compare the attack rates of multiple sclerosis (MS) exacerbations in patients with upper respiratory infections (URIs), focusing on those caused by COVID-19 versus other non-COVID-19 infections.
- Researchers followed 362 patients with relapsing-remitting MS over one year, using MRI scans to track any relapses and symptoms every 12 weeks.
- Findings showed that both COVID-19 and non-COVID-19 URIs significantly increased the risk of MS attacks, with similar exacerbation rates and no significant change in MRI lesions during these episodes.
Article Abstract
Background: Although upper respiratory infections (URIs) are linked to multiple sclerosis (MS) attacks, SARS-COV2 has not been compared to URIs for attack rates.
Objectives: This study aimed to evaluate the attack rate and the results of neuroimaging in MS patients with URIs caused by COVID-19 and non-COVID-19 infections (NC-URI).
Methods: From May 2020 to April 2021, we followed 362 patients with relapsing-remitting MS in a prospective cohort design. Patients were monitored regularly every 12 weeks; an magnetic resonance imaging (MRI) scan was performed at enrollment and every time a relapse occurred. Poisson analysis was used to determine exacerbation rate ratios (RR) and the MRI parameters were tested using chi-square analysis.
Results: 347 patients with an average age of 38 and a female ratio of 86% were included. A RR of 2.24 ( < 0.001) was observed for exacerbations during the at-risk period (ARP). Attacks related to COVID-19 (RR = 2.13, = 0.001) and NC-URIs (RR = 2.39, < 0.001) were comparable regarding the increased risk of exacerbation ( = 0.62). Exacerbations within or outside the ARP did not significantly alter the number of baseline GAD-enhancing lesions ( > 0.05 for both).
Conclusion: COVID-19 has been shown to increase the risk of MS exacerbations, like other viral URIs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521289 | PMC |
| http://dx.doi.org/10.1177/20552173231196992 | DOI Listing |
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