AI Article Synopsis
- Many patients experience long COVID (LC), and this study compared their immune responses to those who fully recovered (HC) during the Omicron wave.
- Researchers enrolled 292 patients with confirmed COVID infections and found that neutralizing antibodies were significantly lower against the BA.1 and BA.5 variants in both groups, especially for those vaccinated with fewer doses.
- The study suggests that those with long COVID may need booster vaccinations sooner after infection to improve T cell function, as certain T cell subsets were found to be reduced in LC patients.
Article Abstract
Many patients develop post-acute COVID syndrome (long COVID (LC)). We compared the immune response of LC and individuals with post-COVID full recovery (HC) during the Omicron pandemic. Two hundred ninety-two patients with confirmed COVID infections from January to May 2022 were enrolled. We observed anti-SARS-CoV-2 receptor-binding domain immunoglobulin G, surrogate virus neutralization test, T cell subsets, and neutralizing antibodies against Wuhan, BA.1, and BA.5 viruses (NeuT). NeuT was markedly reduced against BA.1 and BA.5 in HC and LC groups, while antibodies were more sustained with three doses and an updated booster shot than ≤2-dose vaccinations. The viral neutralization ability declined at >84-days after COVID-19 onset (PC) in both groups. PD1-expressed central and effector memory CD4 T cells, and central memory CD8 T cells were reduced in the first months PC in LC. Therefore, booster vaccines may be required sooner after the most recent infection to rescue T cell function for people with symptomatic LC.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535557 | PMC |
| http://dx.doi.org/10.3390/vaccines11091413 | DOI Listing |
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