AI Article Synopsis
- Identifying bioactive molecules from marine organisms, particularly fish, remains largely unexplored, despite their potential benefits.
- Analysis of the Lusitanian toadfish's crude body mucus showed promising antioxidant, antihypertensive, and antimicrobial properties, with specific metrics indicating strong activity levels.
- This study is the first to highlight the bioactive potential of toadfish mucus, suggesting its possible applications in food and pharmaceuticals.
Article Abstract
Identifying bioactive molecules from marine organisms is still vastly understudied. Fish remain an untapped source of bioactive molecules, even when considering species whose toxicity to other fish species has been noticed before. We assessed potential applications of crude body mucus of the Lusitanian toadfish () and characterized its peptide fraction composition. Mucus samples from three individuals (two wild and one captive) revealed potential antioxidant, antihypertensive, and antimicrobial activities. For antioxidant activity, the best results of 2371 ± 97 µmol Trolox Equivalent/g protein for ORAC and 154 ± 6 µmol Trolox Equivalent/g protein for ABTS were obtained. For antihypertensive activity, the relevant inhibitory activity of ACE resulted in IC of 60 ± 7 µg protein/mL. Antimicrobial activity was also identified against the pathogenic bacteria and . The peptide profile of the crude body mucus was obtained through size exclusion chromatography, with a conspicuous peak at ca. 800 Da. LC-MS/MS allowed the detection of the most probable peptide sequences of this dominant peptide. This is the first study where the bioactive potential of mucus from the Lusitanian toadfish is demonstrated. Peptides with such properties can be applied in the food and pharmaceutical industries.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537117 | PMC |
| http://dx.doi.org/10.3390/molecules28186458 | DOI Listing |
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