In this paper, we present numerical and experimental results on Localized Surface Plasmon Resonance (LSPR) refractive index (RI) sensitivity, Figure of Merit (FoM), and penetration depth () dependence on spherical gold nanoparticles (AuNPs) size, and the effects of AuNP dimer interparticle distance () studied numerically. These parameters were calculated and observed for = 20, 40, 60, 80, and 100 nm diameter spherical AuNPs. Our investigation shows = 60 nm AuNPs give the best FoM. The AuNP dimer interparticle distance can significantly influence the RI sensitivity. Therefore, the effect of distances between pairs of = 20 nm and 60 nm AuNPs is shown. We discuss the importance of penetration depth information for AuNPs functionalized with aptamers for biosensing in the context of aptamer size.
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http://dx.doi.org/10.3390/mi14091717 | DOI Listing |
Mikrochim Acta
January 2025
School of Public Health, Jilin University, Changchun, Jilin, 130021, P. R. China.
A spherical nucleic acid (SNA, AuNPs-aptamer) into CRISPR/Cas12a system combined with poly T-template copper nanoparticles as fluorescence reporter was fabricated to establish an amplification-free sensitive method for Staphylococcus aureus (S. aureus) detection. This method, named PTCas12a, utilizes the concept that the bifunction of SNA recognizes the S.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
251 Nieuwland Science Hall, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Thermal transport coefficients, notably the interfacial thermal conductance, were determined in planar and spherical gold interfaces functionalized with CTAB (cetyltrimethylammonium bromide) or MTAB (16-mercapto-hexadecyl-trimethylammonium bromide) using reverse nonequilibrium molecular dynamics (RNEMD) methods. The systems of interest included (111), (110), and (100) planar facets as well as nanospheres ( = 10 Å). The effect of metal polarizability was investigated through the implementation of the density-readjusted embedded atom model (DR-EAM), a polarizable metal potential.
View Article and Find Full Text PDFHeliyon
January 2025
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.
Recent advancements in nanoscience underscore the transformative potential of nanomaterials in environmental and biological applications. In this study, we synthesized gold nanoparticles (Au@ NPs) using an eco-friendly and cost-effective approach, leveraging peel extract as both a capping and reducing agent. This method presents a sustainable alternative to traditional chemical agents.
View Article and Find Full Text PDFNano Lett
January 2025
Department of Mechanical Engineering, the University of Texas at Dallas, Richardson, Texas 75080, United States.
Plasmonic nanomaterials are effective photoacoustic (PA) contrast agents with diverse biomedical applications. While silica coatings on gold nanoparticles (AuNPs) have been demonstrated to increase PA efficiency, the underlying mechanism remains elusive. Here, we systematically investigated the impact of silica coatings on PA generation under picosecond and nanosecond laser pulses.
View Article and Find Full Text PDFAnal Chem
January 2025
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.
The CRISPR-Cas12a system has shown tremendous potential for developing efficient biosensors. Albeit important, current CRISPR-Cas system-based diagnostic technologies (CRISPR-DX) highly rely on an additional preamplification procedure to obtain high sensitivity, inevitably leading to issues such as complicated assay workflow, cross-contamination, etc. Herein, a spherical protospacer-adjacent motif (PAM)-antenna-enhanced CRISPR-Cas12a system is fabricated for universal amplification-free nucleic acid detection with a detection limit of subfemtomolar.
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