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Common and specific gene regulatory programs in zebrafish caudal fin regeneration at single-cell resolution.
Genome Res
January 2025
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA;
Following amputation, zebrafish regenerate their injured caudal fin through lineage-restricted reprogramming. Although previous studies have charted various genetic and epigenetic dimensions of this process, the intricate gene regulatory programs shared by, or unique to, different regenerating cell types remain underinvestigated. Here, we mapped the regulatory landscape of fin regeneration by applying paired snRNA-seq and snATAC-seq on uninjured and regenerating fins.
View Article and Find Full Text PDFRare occurrence of upper-limb ischaemia necessitating transhumeral amputation following axillary arterial line placement.
BMJ Case Rep
January 2025
Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
Arterial cannulation, commonly performed in the radial artery, is a widely used method for continuous blood pressure monitoring. Occasionally, the axillary artery is used as an alternate site of cannulation. However, complications like occlusion can lead to adverse events and severe outcomes.
View Article and Find Full Text PDFBioinspired Adhesive Hydrogel Platform with Photothermal Antimicrobial, Antioxidant, and Angiogenic Properties for Whole-Process Management of Diabetic Wounds.
ACS Appl Mater Interfaces
January 2025
Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000, China.
Diabetic wound healing remains a major challenge in modern medicine. The persistent inflammation and immune dysfunction hinder angiogenesis by producing excessive ROS and increasing the susceptibility to bacterial infection. In this study, we developed an integrated strategy for whole-process management of diabetic wounds based on a bioinspired adhesive hydrogel platform with hemostasis, photothermal antimicrobial, antioxidant, anti-inflammatory, and angiogenic properties.
View Article and Find Full Text PDFAssessing walking speed in persons with a lower-limb amputation: Test-retest reliability of the 10-m walk test.
Prosthet Orthot Int
January 2025
School of Physical Education and Physiotherapy, Federal University of Uberlândia (UFU), Minas Gerais, Brazil.
Background: Preferred walking speed (PWS), maximal walking speed (MWS), and walking speed reserve (WSR)-the difference between MWS and PWS-can be easily obtained from the 10-m walk test (10MWT) to assess walking ability and function. However, their test-retest reliability has not been determined in persons with unilateral lower-limb amputation (LLA).
Objectives: To determine the reliability of the PWS, MWS, and WSR obtained from the 10MWT in persons with LLA.
Spatiotemporal gait parameters influencing functional mobility of people with lower limb amputation.
Prosthet Orthot Int
January 2025
Department of Physical Therapy, University of Miami Miller School of Medicine, Coral Gables, FL, USA.
Background: Walking speed is a measure of functional mobility that is relatively easy to quantify. In people with lower limb amputation, reduced walking speed has been linked with specific atypical spatiotemporal gait parameters. However, the influence of atypical spatiotemporal gait parameters on the walking speed of people with unilateral transtibial amputation (TTA) and transfemoral amputation (TFA) remains unclear.
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