() infection is the most common cause of chronic gastritis, peptic ulcers and gastric cancer. Successful colonization of the stomach by is related to the complex interactions of these bacteria and its components with host cells. The growing antibiotic resistance of and various mechanisms of evading the immune response have forced the search for new biologically active substances that exhibit antibacterial properties and limit the harmful effects of these bacteria on gastric epithelial cells and immune cells. In this study, the usefulness of pyomelanin (PyoM) produced by for inhibiting the metabolic activity of was evaluated using the resazurin reduction assay, as well as in vitro cell studies used to verify the cytoprotective, anti-apoptotic and pro-regenerative effects of PyoM in the LPS environment. We have shown that both water-soluble (PyoM) and water-insoluble (PyoM) PyoM exhibit similar antibacterial properties against selected reference and clinical strains of . This study showed that PyoM at a 1 μg/mL concentration reduced -driven apoptosis and reactive oxygen species (ROS) production in fibroblasts, monocytes or gastric epithelial cells. In addition, PyoM enhanced the phagocytosis of . PyoM showed better pro-regenerative and immunomodulatory activities than PyoM.
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| http://dx.doi.org/10.3390/ijms241813911 | DOI Listing |
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