AI Article Synopsis
- Aflatoxin, a known carcinogen, causes significant oxidative damage to organs, particularly the liver, and biological methods are being researched to break it down.
- A new bacterial strain, ZJ20, was isolated from AFB-contaminated environments and shown to effectively degrade aflatoxin B (AFB).
- Genomic analysis of ZJ20 revealed a variety of enzymes with antioxidant and antimicrobial properties, including those specifically designed for AFB degradation, providing insight for future applications in bioremediation.
Article Abstract
As a class I carcinogen, aflatoxin can cause serious damage to various tissues and organs through oxidative stress injuries. The liver, as the target organ of AFB, is the most seriously damaged. Biological methods are commonly used to degrade AFB. In our study, the aflatoxin B-degrading strain ZJ20 was screened from AFB-contaminated feed and soil, and the degradation of AFB by ZJ20 was investigated. The whole genome of strain ZJ20 was analyzed, revealing the genomic complexity of strain ZJ20. The 16S rRNA analysis of strain ZJ20 showed 100% identity to . Through whole gene functional annotation, it was determined that ZJ20 has high antioxidant activity and enzymatic activity; more than 100 CAZymes and 11 gene clusters are involved in the production of secondary metabolites with antimicrobial properties. In addition, ZJ20 was predicted to contain a cluster of genes encoding AFB-degrading enzymes, including chitinase, laccase, lactonase, and manganese oxidase. The comprehensive analysis of provides a theoretical basis for the subsequent development of the biological functions of ZJ20 and the combinatorial enzyme degradation of AFB.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525747 | PMC |
| http://dx.doi.org/10.3390/biology12091195 | DOI Listing |
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Article Synopsis
- Aflatoxin, a known carcinogen, causes significant oxidative damage to organs, particularly the liver, and biological methods are being researched to break it down.
- A new bacterial strain, ZJ20, was isolated from AFB-contaminated environments and shown to effectively degrade aflatoxin B (AFB).
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