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Linear Modelling of the V̇O2/PO-Relationship during Constant Work Rate Exercise.
Med Sci Sports Exerc
January 2025
Department of Movement and Sports Sciences, Ghent University, Ghent, BELGIUM.
Introduction: The linear and continuous increase in power output (PO) during ramp incremental (RI) exercise causes a distinct V̇O2/PO relationship compared to constant work rate (CWR) exercise. Current methods enabling a translation of ramp-derived PO to CWR PO assume a linear development of the CWR V̇O2/PO relationship in the heavy-intensity domain. This study aimed to model the RI versus CWR V̇O2/PO relationship to investigate whether the loss of mechanical efficiency above GET develops linearly.
View Article and Find Full Text PDFAZD2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: two randomized phase I trials.
J Hepatol
January 2025
MASLD Research Center, Division of Gastroenterology and Hepatology, University of California at San Diego, La Jolla, CA, USA.
Background & Aims: A common genetic variant (rs738409) encoding isoleucine to methionine at position 148 in the PNPLA3 protein is a determinant of hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver-related mortality. AZD2693 is a liver-targeted antisense oligonucleotide against PNPLA3 mRNA. We evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics in single ascending dose (SAD) and multiple ascending dose (MAD) studies.
View Article and Find Full Text PDFThe influence of the dry ashing procedure on the correctness of Pb determination in lichens and mosses.
Environ Sci Pollut Res Int
January 2025
V.S. Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of Sciences, 3 Koptuga Av, Novosibirsk, Russia, 630090.
Mosses and lichens are often used to assess atmospheric deposition of Pb. The most widely used method for determining this isotope is gamma spectrometric analysis. There is often a need to enhance the sensitivity of the method, which can be achieved by pre-concentrating Pb.
View Article and Find Full Text PDF'They attacked you just like that': Negotiating racial epistemics in making claims about racism.
Br J Soc Psychol
January 2025
Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Social psychological research on race and racism has shown that claims about racism are not always accepted or received as valid reports. In this paper, I offer racial epistemics as one mechanism by which race-talk takes place. I examine how ascribing category-bound entitlements to experiential or other knowledge about racism is variously realised and complicated in the production of claims about racism.
View Article and Find Full Text PDFResidue Analysis and Dietary Risk Assessment of 10 Neonicotinoid Insecticides in from Hainan Province of China.
Foods
December 2024
Key Laboratory of Tropical Fruits and Vegetables Quality and Safety, State Administration for Market Regulation, Hainan Academy of Inspection and Testing, Haikou 571199, China.
In this study, residues of 10 neonicotinoid insecticides were tested with 143 fresh samples of using the QuEChERS method combined with UPLC-MS/MS. Based on the residue results, the point estimation method was used to assess dietary risks for adults and children, and the cumulative risk was assessed according to the hazard index () and relative potency factor () methods. The results showed that 71 out of 143 samples of fresh sold in Hainan tested positive for neonicotinoid insecticides, with a detection rate of 49.
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