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Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells.
Nat Protoc
November 2024
Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.
Article Synopsis
- * Detailed protocols are provided for preparing and expanding airway basal stem cells from mice and induced pluripotent stem cells, followed by methods for their transplantation into mice.
- * Successful engraftment leads to the restoration of key airway functions and cell types, with timelines for generating and using these stem cells outlined for researchers.
Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models.
J Vis Exp
July 2024
Department of Pathology, Johns Hopkins University School of Medicine; Sidney Kimmel Comprehensive Cancer Center; Department of Urology, Johns Hopkins University School of Medicine;
Oral gavage (OG) with the use of a cannula attached to a syringe is one of the most common methods used to deliver precise dosing of compounds to the stomach of research animals. Unfortunately, this method comes with difficulties for both the operator and the research animal. Studies have shown that OG may lead to complications, including esophagitis, perforation of the esophagus, and inadvertent tracheal drug administration.
View Article and Find Full Text PDFChanges in the Proportion of Each Cell Type After hiPSC-Derived Airway Epithelia Transplantation.
Cell Transplant
February 2024
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
No radical treatment is available for the regeneration of dysfunction and defects in airway epithelia. Artificial tracheae made of polypropylene and collagen sponge were used in clinical studies to reconstitute tracheae after resection. For early epithelialization of the luminal surface of the artificial trachea, a model was established, that is, an artificial trachea covered with human-induced pluripotent stem cell-derived airway epithelial cells (hiPSC-AECs) was transplanted into a tracheal defect in an immunodeficient rat.
View Article and Find Full Text PDFThe U- advancement Burrow's Flap in Persistent Tracheocutaneous Fistula. ~ Case Report.
Indian J Otolaryngol Head Neck Surg
December 2023
Dept of ORLHNS, Dayanand Medical College, Ludhiana, Punjab India.
Persistent tracheo-cutaneous fistulae necessitate a closure with pedicled or free flaps. The modality adopted is to reconstitute the anterior tracheal wall without compromising the tracheal lumen. We have developed the lateral U advancement Burrow's flap over the strap muscles and tracheal lateral fibrous flaps, to repair a large trachea-cutaneous fistula.
View Article and Find Full Text PDFDecreased fucosylation impacts epithelial integrity and increases risk for COPD.
bioRxiv
November 2023
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
COPD causes significant morbidity and mortality worldwide. Epithelial damage is fundamental to disease pathogenesis, although the mechanisms driving disease remain undefined. Published evidence from a COPD cohort (SPIROMICS) and confirmed in a second cohort (COPDgene) demonstrate a polymorphism in is a trans-pQTL for E-cadherin, which is critical in COPD pathogenesis.
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