Structural insight into EV-A71 3A protein and its interaction with a peptide inhibitor.

Virol Sin

Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Published: December 2023

• Our results disclosed a dihelical structure of Enterovirus A71 3A protein in apo form. • We depicted rigid helices and a unique flexible C-terminus for apo-form 3A. • This study revealed a competitive binding-based molecular mechanism underlying inhibition of dimeric 3A by ER-DRI.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786657PMC
http://dx.doi.org/10.1016/j.virs.2023.09.004DOI Listing

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