AI Article Synopsis
- This study examined the effects of anodic oxidation on the surface of high oxygen concentration titanium (HOC-Ti) to create a micro/nano composite structure and evaluated its suitability as a dental implant material.
- The modified surface (HOC-NT) showed excellent hydrophilicity and surface roughness, leading to improved biocompatibility when tested with specific cell lines in both in vitro and in vivo settings.
- Results indicated accelerated bone formation and stable integration of HOC-NT implants, highlighting their potential for successful application in dental implants due to enhanced physicochemical and biological properties.
Article Abstract
This study investigated the properties of the micro/nano composite structure on the surface of high oxygen concentration titanium (HOC-Ti) after anodic oxidation modification (HOC-NT) and evaluated its biocompatibility as a dental implant material in vitro and in vivo. HOC-Ti was produced by titanium powders and rutile powders using the powder metallurgy method. Its surface was modified by anodic oxidation. After detecting the electrochemical characteristics, the surface properties of HOC-NT were investigated. MC3T3 and MLO-Y4 cells were employed to evaluate the biocompatibility of HOC-NT and cocultured to study the effects of the changes in osteocytes induced by HOC-NT on osteoblasts. While, its possible mechanism was investigated. In addition, osseointegration around the HOC-NT implant was investigated through in vivo experiments. The results showed that a unique micronano composite structure on the HOC-Ti surface with excellent hydrophilicity and suitable surface roughness was created after anodic oxidation promoted by its electrochemical characteristics. The YAP protein may play an important role in regulating bone remodeling by β-catenin and Rankl/OPG Signaling Pathways. An in vivo study also revealed an accelerated formation rate of new bone and more stable osseointegration around the HOC-NT implant. In view of all experimental results, it could be concluded that the unique morphology of HOC-NT has enhanced physicochemical and biological properties. The promotion of bone formation around implants indicated the feasibility of HOC-NT for applications in oral implants.
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| http://dx.doi.org/10.1016/j.bioadv.2023.213631 | DOI Listing |
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