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Diastereoselective synthesis and biological evaluation of new fluorine-containing α-aminophosphonates as anticancer agents and scaffold to human urokinase plasminogen activator inhibitors.
Eur J Med Chem
February 2025
Adam Mickiewicz University, Faculty of Chemistry, Uniwersytetu Poznańskiego 8, 61-614, Poznań, Poland. Electronic address:
Phosphonate analogues of α-amino acids are increasingly valued for their significant potential in medicinal chemistry. Fluorine is a "magic" element that plays a huge role in modulating the properties of organic compounds. In this work, we combined the two pharmacophores in the synthesis of three series of new α-aminophosphonates.
View Article and Find Full Text PDFTranscriptome Analysis of Porphyromonas gingivalis Lipopolysaccharide-Induced Early Gene Expression in Human Gingival Keratinocytes.
J Periodontal Res
October 2024
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, British Columbia, Canada.
Aim: Porphyromonas gingivalis lipopolysaccharide (PgLPS) is a significant virulence factor and a driver of early innate immune responses in epithelial cells. The presence of PgLPS in immediate proximity to gingival epithelium induces significant inflammatory responses. In primary human gingival keratinocytes (HGK), we utilized transcriptome analysis to elucidate the change in early gene expression induced by PgLPS.
View Article and Find Full Text PDFEffect of calcium concentration on metastasis of hepatocellular carcinoma cells cultured in alginate gel beads.
Colloids Surf B Biointerfaces
January 2025
Innovative Engineering Technology Research Center for Cell Therapy, Shengjing Hospital of China Medical University, Shenyang, China; Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. Electronic address:
Article Synopsis
- Changes in sodium alginate and calcium ion concentrations affect the structure of calcium alginate gel beads, which in turn impacts the behavior of cells encapsulated in them.
- A study found that hepatocellular carcinoma (HCC) cells had a greater ability to invade when encapsulated in beads with a higher calcium concentration (200 mM) compared to a lower concentration (50 mM).
- The higher calcium concentration also led to increased expression of metastasis-related genes and proteins, making these ALG beads a useful tool for studying liver cancer metastasis and testing new drugs.
Enhanced-permeability delivery system for hydroxyl radical-responsive NIR-II fluorescence-monitored thrombolytic therapy.
Colloids Surf B Biointerfaces
January 2025
The Radiology Department of Shanxi Provincial Peoples Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address:
Article Synopsis
- Pathological thrombus can lead to severe health issues like heart attacks and strokes, complicating effective treatment and monitoring.
- Researchers developed a multifunctional nanoplatform (TG-OPDEA@UK/MnO-H1080) to enhance thrombus penetration and enable real-time monitoring through advanced fluorescence imaging.
- The nanoparticles, designed to carry a thrombolytic agent and a fluorescent marker, displayed a significant increase in therapeutic effectiveness while minimizing bleeding risks in a mouse model.
Structure, Properties and Degradation of Self-Assembled Fibrinogen Nanofiber Scaffolds.
ACS Appl Bio Mater
September 2024
Institute for Biophysics, University of Bremen, Otto-Hahn-Allee 1, 28359 Bremen, Germany.
Article Synopsis
- * The study examined how factors like scaffold layering, cross-linking time, and freeze-drying impact the stability and properties of these nanofibers, finding that cross-linking with formaldehyde vapor offers optimal stability.
- * Results show that different cross-linking times alter mechanical properties without changing hydration, and the nanofibers have a higher susceptibility to enzyme degradation compared to planar forms, highlighting their potential in soft tissue applications.
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