AI Article Synopsis

  • * The occurrence of HLA-B*57:01 was similar in patients with PML (6.19%) and those without (5.08%), indicating no significant difference.
  • * Clinical and biological characteristics, as well as outcomes for PML, were unaffected by the HLA-B*57:01 status among those diagnosed with PML.

Article Abstract

Among 34,351 patients living with human immunodeficiency virus with available HLA-B*57:01 included in the Dat'AIDS cohort, 194 patients (0.56%) had a history of progressive multifocal leukoencephalopathy (PML) and 1,746 (5.08%) were carriers of HLA-B*57:01. The frequency of HLA-B*57:01 was similar among patients with history of PML compared with patients without a history of PML (6.19% [95% confidence interval, CI 2.8%-9.6%] vs. 5.08% [95% CI 4.8%-5.3%];  = .48). Among patients with PML, clinical and biological characteristics at PML diagnosis and the PML outcome were not different according to HLA-B*57:01 status.

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http://dx.doi.org/10.1089/AID.2023.0050DOI Listing

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