Deoxynivalenol (DON) is an important virulence factor of the head blight of wheat and threatens the health of humans. The effect of fungicides on DON production after stressing wheat to produce HO and the effect of nontarget pesticides on DON accumulation are largely unknown. Five pesticides were selected to explore the effect of pesticide-induced oxidative stress on DON production in vitro and in vivo. Epoxiconazole and hexaconazole significantly induced an increase in HO in vitro, and HO further stimulated the production of DON and the expression of the Tri5 gene. Imidacloprid, isoproturon, and mesosulfuron-methyl had no direct effect in vitro. All pesticides activated the activities of superoxide dismutase, catalase, and peroxidase in wheat and caused the excessive accumulation of HO. However, excessive HO did not stimulate the accumulation of DON. Imidacloprid indirectly stimulated the production of DON in vivo, which may be due to its impact on the secondary metabolism of wheat. In brief, pesticide-induced HO in vitro is an important factor in stimulating DON production, but the stressed physiological HO in wheat is not sufficient to stimulate DON production. The bioaccumulation results indicated that imidacloprid and epoxiconazole increase the risk of DON contamination, especially under field spraying conditions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535342 | PMC |
| http://dx.doi.org/10.3390/toxics11090768 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Don't Sleep on Vitamin D: Vitamin D is Associated with Sleep Variability in Apparently Healthy Adults.
Am J Physiol Regul Integr Comp Physiol
January 2025
Neurovascular Physiology Laboratory, School of Kinesiology, Auburn University, Auburn, AL, USA 36849.
Vitamin D is associated with sleep quality and duration, but it's unclear whether vitamin D status influences sleep variability. Therefore, we sought to determine whether vitamin D status was associated with sleep variability in healthy adults. We assessed objective sleep, including timing and duration standard deviation () using the Philips Actiwatch Spectrum and subjective sleep quality using the Pittsburgh Sleep Quality Index (PSQI) in 130 adults.
View Article and Find Full Text PDF[The many ways flowers send signals to pollinators].
Biol Aujourdhui
January 2025
Institut d'Écologie et des Sciences de l'Environnement de Paris (iEES Paris), Paris, France - Sorbonne Université, 4 place Jussieu, 75005 Paris, France.
The evolutionary success of angiosperms, which make up more than 95 percent of the world's terrestrial flora, is largely based on their interactions with animal pollinators. Indeed, it is estimated that, on average, 87.5 percent of flowering plants are pollinated by animals.
View Article and Find Full Text PDFDon't break the bank: Description of survivors in high-volume transfusion and utility of transfusion in trauma.
Surgery
January 2025
Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Introduction: In response to blood shortages, providers face pressure to conserve blood. No metrics exist to calculate transfusion utility. We describe characteristics of survivors after high-volume resuscitation and evaluate transfusion utility in low-volume and high-volume resuscitation.
View Article and Find Full Text PDFMetabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells.
Foods
January 2025
Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Deoxynivalenol (DON), fumonisin B (FB), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans and animals. Single and combined exposure of DON, FB, and ZEN leads to intestinal toxicity but the toxicology mechanism research is still limited. In this study, we explored the cytotoxicity effects of DON, FB, ZEN, and their combination in rat intestinal epithelial cell line 6 (IEC-6) cells.
View Article and Find Full Text PDFThe First Large Identification of 3ANX and NX Producing Isolates of in Manitoba, Western Canada.
Toxins (Basel)
January 2025
Manitoba Agriculture, 65-3rd Avenue NE, Carman, MB R1N 1Y7, Canada.
Fusarium head blight, caused by , continues to be one of the most important and devastating fungal diseases on cereal grains including wheat, barley, and oat crops. produces toxic secondary metabolites that include trichothecene type A and type B mycotoxins. There are many variants of these toxins that are produced, and in the early 2010s, a novel type A trichothecene mycotoxin known as 3ANX (7-α hydroxy,15-deacetylcalonectrin) and its deacetylated product NX (7-α hydroxy, 3,15-dideacetylcalonectrin) were identified in Minnesota, USA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!