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| http://dx.doi.org/10.1007/s40119-023-00330-9 | DOI Listing |
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Transcriptome-wide association study identifies genes associated with bladder cancer risk.
Sci Rep
January 2025
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Genome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear. To extend GWAS findings, we conducted a transcriptome-wide association study (TWAS) using PrediXcan to predict gene expression levels in whole blood using genome-wide genotype data for 6180 bladder cancer cases and 5699 controls included in the database of Genotypes and Phenotypes (dbGaP). Logistic regression was used to estimate adjusted gene-level odds ratios (OR) per 1-standard deviation higher expression with 95% confidence intervals (CI) for bladder cancer risk.
View Article and Find Full Text PDFImpact of exposure to opioids in pregnancy on offspring developmental outcomes in the preschool years: an umbrella review.
BMJ Paediatr Open
January 2025
School of Health Sciences, University of Dundee, Dundee, UK
Background: Early child development sets the course for optimal outcomes across life. Increasing numbers of children worldwide are exposed to opioids in pregnancy and frequently live in environments associated with adverse developmental outcomes. Although multiple systematic reviews have been published in this area, they use different exposures and different types of outcomes.
View Article and Find Full Text PDFNeuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.
JAMA Netw Open
December 2024
Department of Psychological and Brain Sciences, Washington University in St Louis, Missouri.
Importance: The extent to which neuroanatomical variability associated with early substance involvement, which is associated with subsequent risk for substance use disorder development, reflects preexisting risk and/or consequences of substance exposure remains poorly understood.
Objective: To examine neuroanatomical features associated with early substance use initiation and to what extent associations may reflect preexisting vulnerability.
Design, Setting, And Participants: Cohort study using data from baseline through 3-year follow-up assessments of the ongoing longitudinal Adolescent Brain Cognitive Development Study.
Biomarkers.
Alzheimers Dement
December 2024
Laboratory of Alzheimer's Neuroimaging and Epidemiology - LANE, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Background: This study investigated microstructural features of the locus coeruleus to entorhinal cortex pathway (LC-EC) in relation to amyloid (A), tau (T), neurodegeneration (N) markers and cognitive impairment in memory clinic patients.
Method: 124 participants were recruited from the Geneva Memory Clinic (n=30 cognitively unimpaired - CU; n=80 MCI and n=14 dementia - CI) and underwent clinical assessment, 3T MRI scan including diffusion weighted imaging, amyloid PET, and tau PET. Diffusivity indices (fractional anisotropy - FA, mean, axial and radial diffusivities - MD, AxD, RD) were assessed in the LC-EC pathway using a probabilistic atlas.
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Alzheimers Dement
December 2024
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Brain age (BA) prediction models have emerged as valuable tools for understanding individual differences in trajectories of brain aging. These models aim to estimate overall brain health by predicting BA based on structural MRI data. To enhance the specificity of existing BA models, we introduce a deep learning-based BA prediction model.
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