The stable calcium (Ca) isotopes offer a minimally invasive method for assessing Ca balance in the body, providing a new avenue for research and clinical applications. In this study, we measured the Ca isotopic composition of soft tissues (brain, muscle, liver, and kidney), mineralized tissue (bone), and blood (plasma) from 10 mice (5 females and 5 males) with three different genetic backgrounds and same age (3 months old). The results reveal a distinctive Ca isotopic composition in different body compartments of mice, primally controlled by each compartment's unique Ca metabolism and genetic background, independent of sex. The bones are enriched in the lighter Ca isotopes (δCa = - 0.10 ± 0.55 ‰) compared to blood and other soft tissues, reflecting the preferential incorporation of lighter Ca isotopes through bone formation, while heavier Ca isotopes remain preferentially in blood. The brain and muscle are enriched in lighter Ca isotopes (δCa = - 0.10 ± 0.53 ‰; δCa = 0.19 ± 0.41 ‰) relative to blood and other soft tissues, making the brain the isotopically lightest soft tissues of the mouse body. In contrast, the kidney is enriched in heavier isotopes (δCa = 0.86 ± 0.31 ‰) reflecting filtration and reabsorption by the kidney. This study provides important insight into the Ca isotopic composition of various body compartments and fluids.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00216-023-04962-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Experimental Investigation of Cadmium Isotope Fractionation during Adsorption on Montmorillonite and Kaolinite.
Environ Sci Technol
January 2025
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, PR China.
Cadmium (Cd) isotopes have recently emerged as novel tracers of Cd sources and geochemical processes. Widespread clay minerals play a key role in Cd migration due to their strong adsorption capacity, but the mechanism of Cd isotope fractionation during adsorption onto clay minerals is poorly understood. Here, we experimentally investigated the adsorption mechanisms of Cd on montmorillonite (2:1) and kaolinite (1:1) by using extended X-ray absorption fine structure (EXAFS) spectroscopy.
View Article and Find Full Text PDFTracking hydrothermal infiltration within light oil reservoirs using organic geochemical proxies in the Shunbei area of Tarim Basin in China.
Sci Rep
January 2025
Northwest Oilfield Company, SINOPEC, Ürümqi, 830011, China.
Deep oil reservoirs are becoming increasingly significant fields of hydrocarbon exploration in recent decades. Hydrothermal fluid flow is deemed as a potentially crucial factor affecting the occurrence of deep oil reservoirs, such as enhancing porosity/permeability of reservoirs, accelerating oil generation and thermal cracking, and modifying organic properties of crude oils. Understanding the interplay between hydrothermal fluids and crude oils would provide useful constraints for reconstructing hydrocarbon accumulation processes and predicting the distribution patterns of crude oils.
View Article and Find Full Text PDFVisible light-responsive enrofloxacin PEC aptasensor based on CN QDs sensitized BiOBr nanosheets.
Anal Chim Acta
February 2025
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China; Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, PR China. Electronic address:
Background: The excessive application of enrofloxacin (ENR) results in residues contaminating both food and the environment. Consequently, developing robust analytical methods for the selective detection of ENR is crucial. The photoelectrochemical (PEC) sensor has emerged as a highly sensitive analytical technique that has seen rapid development in recent years.
View Article and Find Full Text PDFInsights into the separation, enantioseparation and recognition mechanisms of methamphetamine isotopologues on achiral and polysaccharide-based chiral columns in high-performance liquid chromatography.
Anal Chim Acta
February 2025
Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, 0179, Tbilisi, Georgia. Electronic address:
Background: Isotopologues resulting from the labelling of molecules with deuterium have attracted interest due to the isotope effect observed in chemistry and biosciences. Isotope effect may also play out in noncovalent interactions and mechanisms leading to intermolecular recognition. In chromatography, differences in retention time between isotopologues, as well as between isotopomers have been observed resulting in two different elution sequences (isotope effects): the normal isotope effect when heavier isotopologues retain longer than lighter analogues, and the inverse isotope effect featuring the opposite elution order.
View Article and Find Full Text PDFEffects of tire wear particles on freshwater bacterial-fungal community dynamics and subsequent elemental cycles using microcosms.
J Hazard Mater
January 2025
Department of Plankton and Microbial Ecology, Leibniz-Institute of Freshwater Ecology and Inland Fisheries (IGB), Stechlin, Germany; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany. Electronic address:
Ecological impacts of tire wear particles (TWPs) on microbial communities and biogeochemical cycles in freshwater remain largely unknown. Here, we conducted a microcosm experiment to investigate interactions between the overlying water and sediment without and with TWPs addition in a rural vs. urban lake system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!