From marine sponge-associated fungus Hamigera avellanea, thirteen secondary metabolites including a pair of undescribed alkaloid enantiomers (+)-hamiavemin A (4S) (+)-1 and (-)-hamiavemin A (4R) (-)-1. Compound 1 was enantiomers resolved by the Chiralpak AS-3 column, using a hexane/isopropanol mobile phase. Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. The absolute configuration of (+)-1 and (-)-1 were assigned tentatively by ECD calculations. Among the isolates, compound 6 showed strongest antibacterial activity against Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella enterica, and Candida albicans with the MIC values of 2, 2, 16, 32, 64, and 16 μg/mL, respectively, which were stronger than that of the positive control compound, kanamycin (MIC values ranging from 4 to 128 μg/mL). In addition, compounds 1, 2, and 9 showed moderate cytotoxic activity against three cancer cell lines, HepG2, A549, and MCF-7 with the IC50 values ranging from 55.35±1.70 to 83.02±2.85 μg/mL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202301425 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hendersines J-M: Isoquinoline alkaloids from Corydalis hendersonii Hemsl. with cardiomyocyte protective and NO production inhibitory effects.
Phytochemistry
December 2024
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, PR China. Electronic address:
Six isoquinoline alkaloids were identified from the alkaloid-rich fraction of Corydalis hendersonii Hemsl, including five previously undescribed isoquinoline alkaloids hendersines J-M (1a, 1b, and 2-4) and isobicuculline (5), a compound reported for the first time from a natural source. Their structures were elucidated based on spectroscopic analysis of HR-ESI-MS, 1D and 2D NMR, X-ray diffraction, and ECD. Compounds 1a and 1b represent a pair of rare three-nitrogen isoquinoline alkaloid enantiomers, while 2 and 3 are isoquinoline alkaloids featuring a benzo-fused N-heterocycle.
View Article and Find Full Text PDFSesquiterpene enantiomers from Alismatis Rhizoma.
Phytochemistry
December 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China. Electronic address:
A pair of dinor-sesquiterpene enantiomers (1a/1b), eight pairs of guaiane-type sesquiterpenes enantiomers (2a/2b, 3a/3b, 4a/4b, 5a/5b, 6a/6b, 7a/7b, 8a/8b, 9a/9b) and two guaiane-type sesquiterpenes (10, 11), including eleven undescribed ones (1a, 1b, 2a, 2b, 3a, 3b, 4a, 5b, 6a, 10, and 11), were isolated from the aqueous extract of Alismatis Rhizoma. The structures were elucidated by combining 1D and 2D NMR and HRESIMS spectroscopic data. The absolute configurations were determined by experimental and calculated ECD spectra, [Mo(OAc)]-induced ECD spectral analysis, and comparison of the experimental ECD spectra with those of similar analogs.
View Article and Find Full Text PDFSesquiterpenes from the fruits of Piper longum L. and their anti-inflammatory activity.
Fitoterapia
December 2024
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, China; University of Chinese Academy of Sciences, Beijing 100039, China; College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China. Electronic address:
The fruits of Piper longum are called long pepper, which are well-known culinary spice as well as traditional medicine. In present work, thirteen sesquiterpenes including four undescribed compounds were isolated from P. longum fruits.
View Article and Find Full Text PDFMorphology of the unique egg cases of hornsharks (Heterodontiformes: Heterodontidae).
J Fish Biol
October 2024
CSIRO National Research Collections Australia-Australian National Fish Collection, Hobart, Tasmania, Australia.
Many of the egg cases of oviparous chondrichthyans remain unknown and undescribed in the literature. Egg cases can be a useful taxonomic character for species distinction and can be a valuable indicator of a species distribution in the field. In this study, the egg cases for 9 of the 10 nominal species of Heterodontus are described and compared, and the terminology and methodology for studying them are standardized.
View Article and Find Full Text PDFStudy on the Chemical Components and Anti-neuroinflammatory Activity of the Roots of Clausena excavate Burm. f.
Chem Biodivers
October 2024
School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Article Synopsis
- The ethanol extract from Clausena excavata roots yielded two new coumarins (clauexcatin A and B) and trans/cis isomers of clauexcatin C, in addition to thirty known compounds, including one (compound 33) never before isolated from this genus.
- The structures of these compounds were determined using physicochemical properties and spectroscopic analysis.
- Anti-neuroinflammatory effects were evaluated on BV-2 microglial cells, with certain compounds showing significantly greater inhibition of nitric oxide release compared to the positive control minocycline.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!