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rBet v 1a-BanLec induce upregulation of IL-10 and IFN-γ gene expression in Caco-2/THP-1 co-culture and secretion of IL-10 and IFN-γ/IL-4 levels in PBMCs of birch pollen allergic donors.
Int Immunopharmacol
March 2024
Faculty of Chemistry, University of Belgrade, Belgrade, Serbia. Electronic address:
Novel allergen immunotherapy (AIT) approaches necessitate the use of more effective and safe therapeutics, which can be accomplished by employing novel adjuvants for improved innate immune cell activation, as well as hypoallergenic allergen forms. In this study, we investigate the immunomodulatory effects of a chimera rBet v 1a-BanLec (rBv1a-BL; C) composed of the major birch pollen allergen Bet v 1a and banana lectin (BanLec; BLwt) and two novel chimeras, rBv1l-BL (rBet v 1l-BanLec; C1) and rBL-Bv1l (rBanLec-Bet v 1l; C2), both composed of BL and hypoallergenic birch pollen allergen Bv1l in the co-culture model Caco-2/THP-1, and PBMCs from donors with birch pollen allergy. The chimeric molecules rBv1l-BL (C1) and rBL-Bv1l (C2) were created in silico and then produced in E.
View Article and Find Full Text PDFHypoallergenic chimeric virus-like particles for the development of shrimp tropomyosin allergen Pen m 1-specific blocking antibodies.
Allergy
April 2024
Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
An In Vitro and In Vivo Translational Research Approach for the Assessment of Sensitization Capacity and Residual Allergenicity of an Extensive Whey Hydrolysate for Cow's Milk-Allergic Infants.
Foods
July 2022
Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.
Introduction: Hypoallergenic formulas prepared from hydrolyzed cow's milk proteins are often used for the management of cow's milk allergy (CMA) in infants. In this study, both in vitro assays and an in vivo mouse model for CMA were used to assess the sensitizing and allergenic potential of a newly developed, extensive whey hydrolysate (eWH).
Methods: Gel permeation chromatography was used to characterize the molecular weight distribution of the peptides.
Prophylactic and Therapeutic Effects of Oral Immunotherapy on Birch Pollen-Induced Allergic Conjunctivitis in Mice with a Rice-Based Edible Vaccine Expressing a Hypoallergenic Birch Pollen Allergen.
Cells
November 2021
Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.
We investigated the prophylactic and therapeutic effects of the oral administration of transgenic rice seeds expressing a hypoallergenic Bet v 1 derivative of allergic birch pollen conjunctivitis in mice. Transgenic rice seed depositing a chimeric molecule called TPC7 (tree pollen chimera 7) created by DNA shuffling of Bet v 1 family sequences from birch, alder and hazel in protein bodies of endosperm was generated. BALB/c mice were sensitized to birch pollen in alum and challenged with pollen in eyedrops.
View Article and Find Full Text PDFGeneration of a chimeric dust mite hypoallergen using DNA shuffling for application in allergen-specific immunotherapy.
Int J Clin Exp Pathol
May 2015
Department of Physiology, School of Basic Medicine, Wannan Medical College Wuhu 241002, Anhui, China.
Specific immunotherapy (SIT) is the only treatment that provides long lasting relief of allergy symptoms. Unfortunately, SIT-based traditional remedies carry the risk of producing local and/or systemic side effects. To improve the safety and efficacy of SIT, it has been proposed that SIT must utilize allergens that are hypoallergenic but hyperimmunogenic.
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