Aim: The increasing burden of resistance in Gram-negative bacteria (GNB) is becoming a major issue for hospital-acquired infections. Therefore, understanding the molecular mechanisms is important.
Methodology: Resistance genes of phenotypically colistin-resistant GNB (n = 60) were determined using whole genome sequencing. Antimicrobial susceptibility patterns were detected by Vitek®2 & broth microdilution.
Results: Of these phenotypically colistin-resistant isolates, 78% were also genetically resistant to colistin. Activation of efflux pumps, and point-mutations in , and genes conferred colistin resistance among GNB. Eight different strains of were identified and ST43 was the most prominent strain with capsular type-specific (cps) gene KL30.
Discussion: These results, in combination with rapid diagnostic methods, will help us better advice appropriate antimicrobial regimens.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518808 | PMC |
| http://dx.doi.org/10.2144/fsoa-2022-0055 | DOI Listing |
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