Introduction: Denosumab is generally used for 5-10 years to treat postmenopausal osteoporosis. Although atypical fractures caused by bisphosphonate use are well known, reports of denosumab-associated femur fractures are rare.
Case Report: Herein, a 75-year-old woman suffered an atypical periprosthetic femoral fracture 31 months after receiving denosumab. The fracture occurred transverse to the stem tip with lateral cortical thickening. The patient underwent revision surgery for conversion to a longer cemented stem. The fracture site healed 10 months after revision surgery.
Conclusion: As far as we know, there have been no reports of a case on periprosthetic atypical femur fracture associated with denosumab. Our study shows the potential of periprosthetic atypical femoral fractures in patients using denosumab for a long time.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519314 | PMC |
| http://dx.doi.org/10.13107/jocr.2023.v13.i09.3864 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Atypical Periprosthetic Joint Infection Post-Total Knee Arthroplasty: A Case of Actinomyces europaeus.
Cureus
October 2024
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, ROU.
Periprosthetic joint infection (PJI) is a significant complication following total knee arthroplasty (TKA), representing a substantial challenge due to the difficulty in diagnosis and management. The main causes are predominantly common bacteria, but rare pathogens such as can complicate diagnosis and treatment. We report a unique case of a 75-year-old Caucasian patient with a history of multiple comorbidities including obesity, arterial hypertension, total thyroidectomy, rheumatoid arthritis, and prior venous thrombosis.
View Article and Find Full Text PDFPseudotumor in total knee revision arthroplasty resembling heterotopic ossification: A case report.
Int J Surg Case Rep
November 2024
Department of Orthopaedic Surgery, University of Puerto Rico, Medical Sciences Campus, San Juan 00936-5067, Puerto Rico.
Introduction: Pseudotumors are well-known complications following total hip arthroplasty (THA), usually attributed to debris-induced inflammation from direct metal-on-metal contact between implants. In total knee arthroplasty (TKA), the traditional use of polyethylene as a bearing surface prevents direct metal articulation. Thus, pseudotumor formation in TKA usually suggests atypical metal interaction between the prosthetic components.
View Article and Find Full Text PDFAtypical Vancouver B1 periprosthetic fracture of the proximal femur in the United Kingdom: a case report challenged by myeloma, osteoporosis, infection, and recurrent implant failures.
J Trauma Inj
March 2024
Department of Trauma and Orthopaedics, North Manchester General Hospital, Manchester, UK.
Article Synopsis
- Total hip replacement indications are expanding beyond osteoarthritis to include trauma and pathological fractures in active patients, leading to more complications like periprosthetic femoral fractures.
- A case study of a 71-year-old woman highlights challenges in treating these fractures due to factors like poor bone quality, infection, and stress fractures after her hip replacement.
- After multiple interventions including internal fixation and bone grafting, the patient eventually regained her mobility 13 months post-surgery, but complications such as implant failure and nonunion were significant hurdles in her recovery.
Implant-associated infection (IMTI) in long-term, well-fixed implants.
J Clin Orthop Trauma
September 2024
Department of Orthopaedic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Article Synopsis
- Successful treatment of two rare cases of orthopedic device infections (IMTI) was achieved through careful surgical debridement and 18 months of anti-tubercular chemotherapy while retaining the implants.
- Both patients exhibited similar symptoms, including discharging sinuses at surgical sites years after their respective surgeries, but initial cultures were negative.
- The study highlights the importance of analyzing intra-operative tissue samples for further diagnosis and suggests that atypical presentations of infections should be considered for IMTI in similar cases.
Microbiological Differences Among Age Groups in Patients Diagnosed With Periprosthetic Joint Infection: A Database Analysis of 2,392 Patients.
J Am Acad Orthop Surg
August 2024
From the Granovsky Gluskin Division of Orthopaedic Surgery, Sinai Health, University of Toronto, Toronto, Canada (Ekhtiari), the Marienhospital Gelsenkirchen, Gelsenkirchen, Germany (Mai), and the Helios ENDO Klinik, Hamburg, Germany (Ekhtiari, Mai, Karlidag, Gehrke, and Citak).
Introduction: Periprosthetic joint infection (PJI) after total joint arthroplasty (TJA) poses substantial economic and quality-of-life challenges. With the rising incidence of hip and knee arthritis globally, understanding the changing profile of PJIs across different age groups becomes crucial. While various studies have explored risk factors, the influence of age on PJI remains debated, with potential bimodal relationships.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!