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| http://dx.doi.org/10.3389/fimmu.2023.1216402 | DOI Listing |
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Deep profiling deconstructs features associated with memory CD8 T cell tissue residence.
Immunity
December 2024
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:
Tissue-resident memory CD8 T (Trm) cells control infections and cancer and are defined by their lack of recirculation. Because migration is difficult to assess, residence is usually inferred by putative residence-defining phenotypic and gene signature proxies. We assessed the validity and universality of residence proxies by integrating mouse parabiosis, multi-organ sampling, intravascular staining, acute and chronic infection models, dirty mice, and single-cell multi-omics.
View Article and Find Full Text PDFCD69CD103CD8 tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer.
Cell Commun Signal
December 2024
Department of General Surgery, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China.
Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate of patient mortality. CD8 tissue-resident memory T (TRM) cells are strategically positioned to mediate effective anti-tumor responses.
View Article and Find Full Text PDFRegulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease.
Cell Commun Signal
December 2024
Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Tissue-resident memory T (TRM) cells are populations which settle down in non-lymphoid tissues instead of returning to secondary lymph organs after the antigen presentation. These cells can provide rapid on-site immune protection as well as long-term tissue damage. It is reported that TRM cells from small intestine and colon exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional and functional heterogeneity.
View Article and Find Full Text PDFInduction of tissue resident memory T cells by measles vaccine vector.
Hum Vaccin Immunother
December 2024
Interactions hôte-pathogène, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
Measles live attenuated vaccine (MV) induces strong humoral and cellular systemic memory responses allowing the successful control of measles since decades. MV has also been adapted into a promising vaccine platform with several vaccine candidates in clinical development. To understand and document the tissue-scaled memory response induced by MV, we explored the specific induction and persistence of resident memory T cells (Trm) in the lungs and the liver, two critical targeted tissues for vaccine development against several diseases.
View Article and Find Full Text PDFAirway-resident memory CD4 T-cell activation accelerates antigen presentation and T-cell priming in draining lymph nodes.
JCI Insight
December 2024
Burnett School of Biomedical Sciences, Division of Immunity and Pathogenesi, University of Central Florida, Orlando, United States of America.
Specialized memory CD4 T cells that reside long-term within tissues are critical components of immunity at portals of pathogen entry. In the lung, such tissue-resident memory (TRM) cells are activated rapidly after infection and promote local inflammation to control pathogen levels before circulating T cells can respond. However, optimal clearance of Influenza A virus can require TRM and responses by other virus-specific T cells that reach the lung only several days after their activation in secondary lymphoid organs.
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