Computational methods that can predict hard-to-measure modalities from those that are easier to measure, in a patient-specific manner, play a critical role in personalized medicine. In this issue of Cell Reports Methods, Khurana et al. present differential gene targets of accessible chromatin (DGTAC), an approach which predicts patient-specific enhancer-promoter interactions.
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http://dx.doi.org/10.1016/j.crmeth.2023.100594 | DOI Listing |
Nat Commun
May 2024
Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic and transcriptional heterogeneity thought to render these tumors aggressive, resistant to therapy, and inevitably recurrent. However, little is known about how the spatial organization of GBM genomes underlies this heterogeneity and its effects. Here, we compile a cohort of 28 patient-derived glioblastoma stem cell-like lines (GSCs) known to reflect the properties of their tumor-of-origin; six of these were primary-relapse tumor pairs from the same patient.
View Article and Find Full Text PDFGenes (Basel)
September 2023
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Mesenchymal stem cells (MSC) are multipotent stem cells that can differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes. Osteoblast differentiation is reduced during osteoporosis development, resulting in reduced bone formation. Further, MSC isolated from different donors possess distinct osteogenic capacity.
View Article and Find Full Text PDFCell Rep Methods
September 2023
Wisconsin Institute for Discovery, 330 N. Orchard Street, Madison, WI 53715, USA; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53715, USA. Electronic address:
Computational methods that can predict hard-to-measure modalities from those that are easier to measure, in a patient-specific manner, play a critical role in personalized medicine. In this issue of Cell Reports Methods, Khurana et al. present differential gene targets of accessible chromatin (DGTAC), an approach which predicts patient-specific enhancer-promoter interactions.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!