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http://dx.doi.org/10.1002/jhm.13210 | DOI Listing |
J Med Chem
January 2025
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Since decades after temozolomide was approved, no effective drugs have been developed. Undoubtedly, blood-brain barrier (BBB) penetration is a severe issue that should be overcome in glioblastoma multiforme (GBM) drug development. In this research, we were inspired by linezolid through structural modification with several bioactive moieties to achieve the desired brain delivery.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Inner Mongolia Key Laboratory of Rare Earth Catalysis, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, PR China.
Understanding the mechanism of the nitrogen reduction reaction (NRR) is essential for designing highly efficient catalysts. In this study, we investigated the effects of the metal-support interaction (MSI) on NRR using density functional theory. The simulations revealed that the MSI is weak in the Au/BiOCl system, with charge accumulation and depletion primarily occurring within the Au cluster.
View Article and Find Full Text PDFJMIR Form Res
January 2025
School of Health Studies, Northern Illinois University, DeKalb, IL, United States.
Background: About 53 million adults in the United States offer informal care to family and friends with disease or disability. Such care has an estimated economic value of US $600 million. Most informal caregivers are not paid nor trained in caregiving, with many experiencing higher-than-average levels of stress and depression and lower levels of physical health.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Institute of Chemistry CAS: Institute of Chemistry Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Zhongguancun North First St, 100190, Beijing, CHINA.
The photoelectrochemical (PEC) urea oxidation reaction (UOR) presents a promising half-reaction for green hydrogen production, but the stable resonance structure of the urea molecule results in sluggish kinetics for breaking the C-N bond. Herein, we realize the record PEC UOR performance on a NiO-modified n-Si photoanode (NiO@Ni/n-Si) by harnessing the adsorbate-adsorbate interaction. We quantificationally unveil a dependence of the UOR activation barrier on the coverage of photogenerated surface high-valent Ni-oxo species (NiIV=O) by employing operando PEC spectroscopic measurements and theoretical simulations.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!