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http://dx.doi.org/10.2217/fmb-2023-0105 | DOI Listing |
Microb Biotechnol
January 2025
Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.
The increasing threat of antibiotic resistance underscores the urgent need for innovative strategies to combat infectious diseases, including the development of antivirulants. Microbial pathogens rely on their virulence factors to initiate and sustain infections. Antivirulants are small molecules designed to target virulence factors, thereby attenuating the virulence of infectious microbes.
View Article and Find Full Text PDFWorld J Microbiol Biotechnol
January 2025
Clinical Medical College, Changchun University of Chinese Medicine, Changchun, China.
In addressing the formidable challenge posed by methicillin-resistant Staphylococcus aureus (MRSA), this investigation elucidates a novel therapeutic paradigm by specifically targeting the virulence factor sortase A (SrtA) utilizing Tubuloside A (TnA). SrtA plays a critical role in the pathogenicity of MRSA, primarily by anchoring surface proteins to the bacterial cell wall, which is crucial for the bacterium's ability to colonize and infect host tissues. By inhibiting SrtA, TnA offers a novel and distinct strategy compared to traditional antibiotics.
View Article and Find Full Text PDFFront Pharmacol
May 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
J Biomol Struct Dyn
February 2024
Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey.
The virulence factor Type IV pili (T4P) are surface appendages used by the opportunistic pathogen for twitching motility and adhesion in the environment and during infection. Additionally, the use of these appendages by for biofilm formation increases its virulence and drug resistance. Therefore, attenuation of the activity of T4P would be desirable to control infections.
View Article and Find Full Text PDFFuture Microbiol
November 2023
Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes (LEAMER), Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
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