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Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis.
Cell Commun Signal
January 2025
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Background: Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear apoptotic cells, plays a key role in successful wound healing. However, the precise impact of SAVs on wound repair and efferocytosis remains unknown.
View Article and Find Full Text PDFPS-MPs Induced Inflammation and Phosphorylation of Inflammatory Signalling Pathways in Liver.
Toxics
December 2024
Shanghai Municipal Center for Disease Control & Prevention, Shanghai 200336, China.
As new pollutants, microplastics (MPs) have attracted much attention worldwide because they cause serious environmental pollution and pose potential health risks to humans. However, the toxic effects of MPs are still unclear. In this study, we analysed the inflammatory effects of 0.
View Article and Find Full Text PDFSilencing FOXA1 suppresses inflammation caused by LPS and promotes osteogenic differentiation of periodontal ligament stem cells through the TLR4/MyD88/NF-κB pathway.
Biomol Biomed
December 2024
Department of Stomatology, Tianjin First Central Hospital, Nankai District, Tianjin, China.
Article Synopsis
- Human periodontal ligament stem cells (hPDLSCs) are essential for periodontal tissue regeneration, and the study investigates the role of FOXA1 in periodontal inflammation and osteogenic differentiation of these cells.
- Results indicate that FOXA1 expression increases in periodontal tissues from periodontitis patients and is further elevated by LPS treatment, leading to inflammatory responses and reduced osteogenic differentiation.
- Silencing FOXA1 can decrease inflammation by inhibiting the TLR4/MyD88/NF-κB pathway and enhance the osteogenic differentiation of hPDLSCs despite LPS-induced suppression.
Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways.
Sci Rep
January 2025
Department of Critical Care Medicine, Tongde Hospital of Zhejiang Province, #234 Gucui Road, Hangzhou, 310012, Zhejiang, People's Republic of China.
The intestinal barrier function is a critical defense mechanism in the human body, serving as both the primary target and initiating organ in cases of sepsis. Preserving the integrity of this barrier is essential for preventing complications and diseases, including sepsis and mortality. Despite this importance, the impact of resveratrol on intestinal barrier function remains unclear.
View Article and Find Full Text PDFLow-dose radiation ameliorates PM2.5-induced lung injury through non-canonical TLR1/TLR2-like receptor pathways modulated by Akkermansia muciniphila.
Ecotoxicol Environ Saf
January 2025
NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China. Electronic address:
Exposure of PM2.5 can cause different degrees of lung injury, which is referred with inflammatory response. Some evidences showed that low-dose radiation (LDR) induces hormesis in immune, however, it is unknown if LDR ameliorates the PM2.
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