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Probiotics interventions modulating gut microbiota composition in individuals with intestinal constipation: Protocol of a systemic review and meta-analysis of randomized controlled trials.
PLoS One
January 2025
Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Introduction: Intestinal constipation is a substantive global health concern, significantly impairing patient quality of life. An emerging view is that the gut microbiota plays a critical role in intestinal function, and probiotics could offer therapeutic benefits. This study aims to consolidate evidence from randomized controlled trials (RCTs) that assess the effectiveness of probiotics in modulating microbiota and ameliorating symptoms of constipation.
View Article and Find Full Text PDFPromotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals.
Adv Nutr
January 2025
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA; School of Nutrition and Public Health, Oregon State University, Corvallis, Oregon, USA. Electronic address:
Aging is associated with the decline of tissue and cellular functions, which can promote the development of age-related diseases like cancer, cardiovascular disease, neurodegeneration, and disorders of the musculoskeletal and immune systems. Healthspan is the length of time an individual is in good health and free from chronic diseases and disabilities associated with aging. Two modifiable factors that can influence healthspan, promote healthy aging, and prevent the development of age-related diseases, are the diet and microbiota in the gastrointestinal tract (gut microbiota).
View Article and Find Full Text PDFRole of the Microbiome and Diet for Response to Cancer Checkpoint Immunotherapy: A Narrative Review of Clinical Trials.
Curr Oncol Rep
January 2025
Department of Oncology, University Hospital of Southern Denmark, Finsensgade 35, Esbjerg, 6700, Denmark.
Purpose Of Review: The advent of checkpoint immunotherapy has dramatically changed the outcomes for patients with cancer. However, a considerable number of patients have little or no response to therapy. We review recent findings on the connection between the gut microbiota and the immune system, exploring whether this link could enhance the effectiveness of immunotherapy.
View Article and Find Full Text PDFGut Microbiota Assembly Begins at Birth and Needs to Be Nurtured.
Nestle Nutr Inst Workshop Ser
November 2024
APC Microbiome Ireland, School of Microbiology and Department of Medicine, University College Cork - National University of Ireland, Cork, Ireland.
Humans maintain symbiotic relationships with complex microbial communities in their intestinal tracts that are paramount to their host's health and development. Given their importance, it is essential for the host to reliably acquire key members of the gut microbiota and assemble communities that provide benefits during important windows of host development. Epidemiological studies over the last 2 decades have convincingly shown that clinical and nutritional factors that disrupt early-life microbiome assembly predispose humans to infections and chronic noncommunicable diseases.
View Article and Find Full Text PDFDesign and Synthesis of BODIPY and Its Application in Inhibiting Intestinal Flora.
ACS Omega
November 2024
Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, Jiangsu 210009, China.
BODIPY-based photosensitizers were synthesized and tested for antimicrobial photodynamic therapy, revealing structural modifications enhancing the photodynamic therapy (PDT) effects. This research may lead to new PDT strategies for treating bacterial infections, including those resistant to traditional antibiotics, and offers insights into the prevention and treatment of Alzheimer's disease through gut microbiota regulation.
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